Zetpil Resveratrol 98%, Trans Resveratrol Suppositories, 30 Count

Our Price: $134.95$141.90

Resveratrol has displayed great potential for supporting antioxidant and anti-inflammatory activity, as well as cardiovascular health. These suppositories provide a much more substantial and bioavailable dose when compared to wine or oral supplements.

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Resveratrol, a polyphenol found in red grapes and wine, has garnered a lot of attention lately for its nutritional properties. Indeed resveratrol has displayed a great deal of potential for supporting antioxidant and anti-inflammatory activity, as well as multiple aspects of cardiovascular health. These suppositories provide a much more substantial and bioavailable dose of resveratrol when compared to red wine.

  • Contains 441 mg of trans-resveratrol from polygonum cuspidatum.
  • Balanced nutritional support of antioxidant and anti-inflammatory activity.
  • Supports blood flow and other standard features of a healthy cardiovascular system.
  • Suppositories provide a larger and more bioavailable dose of resveratrol than wine or oral supplements.
  • Suppositories can be shipped with ice to ensure preservation of shape and potency.

Resveratrol – The Renowned Antioxidant

Resveratrol belongs to a class of polyphenols known as stilbenes. Stilbenes are most commonly found in the skin of red grapes as well as in red wine. When people discuss the potential health benefits of drinking a glass of wine each day, they are often referring to wine’s exceptionally high resveratrol content.

The antioxidant properties of resveratrol have caused it to garner a great deal of positive attention from nutritional experts. Antioxidants are required in the body to stabilize unbalanced electrons in free radicals. If the amount of free radicals within a given area of the body greatly out measures the amount of antioxidants then oxidative stress will occur. Resveratrol works throughout the body as one of many countermeasures against this oxidization.1

Resveratrol Heart Health Support

In addition to its antioxidant properties, resveratrol is also thought to support anti-inflammatory activity. It achieves this by supporting the activation of SIRT1, a gene which is largely responsible for the regulation of inflammation in the body.2 One particular bodily system which is thought to benefit from the anti-inflammatory support of resveratrol is the cardiovascular system. Inflammation restricts blood flood and thus contributes to a number of serious heart health concerns.

Resveratrol is also thought to upregulate endothelial nitric oxide synthase. The endothelium, an inner lining of the blood vessels, uses nitric oxide as a signal to the surrounding muscle to relax, thus supporting improved blood flow.3

The Bioavailability of Resveratrol

Some experts think that the question of whether or not resveratrol can provide substantial nutritional support to a healthy functioning heart is a question of its bioavailability. For example: a liter of red wine contains roughly 12.59 mg resveratrol, whereas as some studies that have shown positive results from resveratrol supplementation utilized as much as 2,000 mg per day.4 Suffice to say, no health experts would recommend that much wine consumption (over 166 liters) for any person on any day!

These suppositories contain a much higher dose of resveratrol (441 mg taken twice daily) than wine. Not only that, but they also provide much higher absorption rates by releasing their contents directly into the porous tissues of the lower bowels, avoiding any degradation in the digestive system that inevitably occurs with wine or oral supplement consumption.


Note: Storing this product at room temperature will not alter the effectiveness or potency. However a firm suppository is necessary for a comfortable and easy insertion. Therefore we recommend that this product be stored in the refrigerator to maintain firmness. If the suppository does become soft, place the suppository in the refrigerator to achieve the firmness needed for comfortable insertion Avoid excessive heat 40°C (104°F). Store in a cool place 8° to 15°C (46° to 59°F) or refrigerate. When using nutritional supplements or nutraceuticals, please inform your physician if you are undergoing treatment for a medical condition healthcare professional.


  • If pregnant, nursing, or undergoing treatment for a medical condition, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

Supplement Facts

Serving Size: 1 suppository
Servings Per Container: 30
Amount Per Serving

trans-resveratrol a natural phenol, from 450 mgs of polygonum cuspidatum

441 mg



Suppository Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives.


Dosage & Use

Click to view detailed instructions on How to Insert Suppositories.

  • 2 per day, before retiring or as directed by healthcare professional.
  • It is recommended that you always attempt to move your bowels prior to inserting the suppository(s) to avoid discharging of the suppository before the suppository can be totally absorbed.
  • It is recommended that the suppository be retained for approximately 30 (thirty) minutes to insure adequate absorption of the nutraceutical, herbal and nutrient ingredients contained herein.
  • To facilitate insertion it is recommended you moisten suppository with warm water.
  • If inserted while lying on one’s side, consider remaining in the supine position for 10 minutes following insertion.


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1. Resveratrol Antioxidant Properties
2. Resveratrol Anti-Inflammatory Properties
3. Resveratrol NO synthase
4. Resveratrol Dosage Info.