Zetpil Honokiol 300 SR, Professional Strength Suppositories, 30 Count

Our Price: $124.95$131.90

Studies have shown that honokiol has potential to support the function of a healthy brain by stimulating GABA receptors. It has been shown in other studies to support healthy cardiovascular and circulatory system function. Highly absorbable suppositories.

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Studies have shown that honokiol has potential to support the function of a healthy brain by stimulating GABA receptors. Additionally, it has been shown in other studies that honokiol gives support to healthy cardiovascular and circulatory systems. Zetpil Honokiol 300 Suspended Release Suppositories are the best way to ensure that the honokiol extracts are properly absorbed and utilized within the body.

  • Designed to support the function of an already healthy brain.
  • Provides nutritional support to those fighting against stress and other minor mental health concerns.
  • Honokiol may play a role in stimulating GABA receptors.
  • May aid in the functionality of healthy cardiovascular and circulatory systems.
  • No degradation through digestion as with oral supplements.
  • Provides maximum absorption rates via suppository form, up to an 85% absorption rate.
  • Made of a proprietary base to allow proper absorption through the intestinal wall.
  • Suppositories can be shipped with ice to ensure preservation of shape and potency.

The Power of Honokiol

Magnolia is a plant that has long been used in traditional Japanese and Chinese nutritional health practices. Honokiol is the active ingredient that is found in the bark of the magnolia tree. Traditionally, honokiol was used to support a healthy and balanced state of mind. Today it is believed to have even greater potential for nutritional support. Research has shown that Honokiol supports the function of a healthy circulatory system.1 It is also thought to provide nutritional aid to the functionality of gamma-Aminobutyric acid (GABA) receptors in the brain by upregulating hippocampal Glutamic acid decarboxylase (GAD), an enzyme which is involved in GABA synthesis. GABA receptors are crucial mechanisms for protecting and facilitating memory and nerve functions.2 Because they are involved in so many aspects of brain health, supporting the process of GABA synthesis and the function of GABA receptors could prove to have a positive effect on those who have brain health concerns as a result of a GABA deficiency, or other similar GABA difficulties.

The Zetpil Suppository Advantage

The suppository base consists of an advanced proprietary blend formulated to achieve the most effective delivery of honokiol. It is also the most comfortable suppository available as it typically melts in as little as 10 -15 minutes with no retention problems. Every ingredient of this safe and non-irritating base exerts a positive effect.

Sustained Release to maximize the absorption rates of honokiol the suppository has been formulated to allow a sustained release of honokiol over a 1 hour period of time for complete absorption of the ingredients into the blood.


Note: Storing this product at room temperature will not alter the effectiveness or potency. However a firm suppository is necessary for a comfortable and easy insertion. Therefore we recommend that this product be stored in the refrigerator to maintain firmness. If the suppository does become soft, place the suppository in the refrigerator to achieve the firmness needed for comfortable insertion Avoid excessive heat 40°C (104°F). Store in a cool place 8° to 15°C (46° to 59°F) or refrigerate. When using nutritional supplements or nutraceuticals, please inform your physician if you are undergoing treatment for a medical condition healthcare professional.


  • If pregnant, nursing, or undergoing treatment for a medical condition, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

*These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.


Supplement Facts

Serving Size: 1 suppository
Servings Per Container: 30

Amount Per Serving

Proprietary blend:

Lower concentration of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol and highest concentration of 98% concentration of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol from the bark Magnolia grandiflora tree.

300 mg

Suppository Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives.


Dosage & Use

Click to view detailed instructions on How to Insert Suppositories.

  • 1-2 per day, before retiring or as directed by healthcare professional.
  • It is recommended that you always attempt to move your bowels prior to inserting the suppository(s) to avoid discharging of the suppository before the suppository can be totally absorbed.
  • To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water.
  • When used as a suppository, this product requires approximately 6 minutes to start to dissolve and begin to be absorbed. However in order to maximize the nutritional effects of Honokiol the suppository has been formulated allow a sustained release of the Honokiol over a 1 hour period of time for complete absorption of the ingredients.
  • Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion.


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1. Honokiol and Circulation
2. Honokiol and GABA