Life Extension MacuGuard Ocular Support with Saffron, Zeaxanthin, Lutein, C3G, and Meso-Zeaxanthin, 60 softgels

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MacuGuard Ocular Support with Saffron is one of the Life Extension vitamins that offer a proprietary blend of nutrients that mimic the body’s natural ratios of lutein, zeaxanthin, and meso-zeaxanthin. Supports vision and overall eye health. Also contains CS3 and alpha-carotene.

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SKU: 01992 Category:


Item Catalog Number: 01992
60 Softgels
Also available: With Astaxanthin

MacuGuard® Ocular Support with Saffron provides a proprietary blend of lutein, trans-zeaxanthin, and meso-zeaxanthin. These three nutrients play an important role in protecting the delicate photoreceptor cells in the retina’s macula from potential light damage. This unique and innovative formula also contains C3G (cyanidin-3-glucoside), a cutting-edge berry flavonoid compound that aids in stimulating regeneration of rhodopsin, a compound in the eyes that helps to support night vision.

  • Each softgel provides total eye nutrition for over-all optical care.
  • Supports the retina’s macula to promote lasting healthy vision.
  • Supports healthy night vision.
  • Contains lutein, trans-zeaxanthin, and meso-zeaxanthin that help supplement diets that are deficient in these ingredients.
  • Aids in protecting the eyes from sun damage and degeneration related to aging.
  • Contains phospholipids for superior absorption.

Life Extension MacuGuard Ocular Support with Saffron offers a proprietary blend of nutrients that include lutein, zeaxanthin, and meso-zeaxanthin, mimicking the body’s own naturally occurring ratios.

Proper vision requires lutein and zeaxanthin, and special carotenoids that are part of our macular pigment.1,8 The macular pigment is a filter that acts as a natural protector for the eyes from damaging blue and ultraviolet (UV) light. Although consuming large quantities of vegetables that contain these important nutrients is beneficial, it is often quite difficult to obtain system wide absorption2 which is critical for the over-all eye health. This is where Phospholipids come into play. The Phospholipids are utilized to support maximum absorption not only into the eye, but in the blood stream as well.2-7 Research indicates that phospholipids aid in the efficient absorption of lutein not only in the retina of the eyes, but equally important, the blood stream, and cell membranes as well.6,7

While Lutein is a heavy lifter when it comes to eye health, Life Extension MacuGuard also supports an increase in zeaxanthin levels, which is also crucial in maintaining the health of your macular pigment.

Life Extension’s proprietary formulation also includes C3G, an antioxidant extracted from European Black Currant. Studies have shown C3G to have a powerful effect on the body’s antioxidant levels.

Combined, all these ingredients work to support various aspects of ocular health and vision including reducing retinal damage, macular degeneration, and increasing UV light protection.8-10

MacuGuard has been reformulated without soybeans, making it more available for those with allergies or intolerance.


  • If pregnant, nursing, or undergoing treatment for a medical condition, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.



Supplement Facts

Serving Size: 1 softgel

Servings Per Container: 60

Amount Per Serving
MacuGuard® proprietary blend: Phospholipids, marigold extract (flower) [providing 10 mg free lutein, 4 mg meso-zeaxanthin & trans-zeaxanthin], mixed carotenoids [providing 1.24 mg α-carotene] 173 mg
Saffron extract (stigma) 20 mg
C3G (Cyanidin-3-glucoside) [from European black currant extract (fruit)] 2.2 mg
Other Ingredients: extra virgin olive oil, gelatin, glycerin, safflower oil, beeswax, palm oil, purified water, cellulose, annatto color, potato maltodextrin.
Contains No: milk, eggs, fish, crustacean shellfish, tree nuts, peanuts, wheat, and soybean.
LuteinPlus® and Mz® are registered trademarks of Nutriproducts Ltd., UK, licensed under U.S. Patents 6,218,436 and p6,329,432.


Dosage & Use

  • Take one softgel daily with or without food, or as recommended by a healthcare practitioner.


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1. J Photochem Photobiol. 2002;68(1):39−44.
2. Nutrients. 2013 April; 5(4): 1169–1185.
3. Nutr Res. 2009;29(8):588−95.
4. Nutrition. 2011 Sep;27(9):960-6.
5. Lipids. 2009 Sep;44(9):799-806.
6. Mol Cell Biochem. 2006 Jan;281(1-2):103-10.
7. J Pharm. 2011 Jun 30;412(1-2):99-105.
8. Macula of retina
9. Astaxanthin, a carotenoid with potential in human health and nutrition.
10. Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo.