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Zetpil Melatonin, 200 mg, 12 Hour Sustained Release Antioxidant Suppositories, 30 Count

Item Number: MLTSR1 | Be the first to review this product!

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List Price: $145.00
Our Price: $119.95
Your Savings: $25.05
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Supplement Overview

Item Catalog Number: MLTSR1
30 Suppositories
Click for Research Links
Click to View Supplement Facts
How to Insert a Suppository
All Suppositories and Creams

Melatonin supplements are capable of providing valuable sleep cycle support and antioxidant activity. While the benefits of melatonin supplementation are undeniable, the bioavailability of orally ingested melatonin is thought to be extremely low. These suppositories dissolve fast but release slow for optimal convenience and vastly superior absorption rates to any oral melatonin supplement.

  • 200 mg dose of highest quality melatonin designed for maximum bioavailability
  • Powerful antioxidant and anti-inflammatory properties
  • Supports the development of a healthy sleep schedule
  • No degradation through digestion as with oral supplements
  • Made of an all-natural proprietary suppository base


Sleep Support and Antioxidant Activity of Melatonin

Many people take melatonin supplements to support the development of a healthy sleep schedule. Indeed, melatonin is a naturally produced hormone which plays a significant role in regulating sleep cycles of the human body. It is synthesized at higher rates in darkness as a preparation for sleep and at lower rates in the light to support energy levels throughout the daytime. Those who experience difficulties with maintaining regularity in their sleep cycle, either for health or work related reasons, may find that melatonin supplementation supports them in developing a healthier sleeping schedule.

While many people use melatonin for sleep support, it is less commonly known that melatonin is among the most powerful antioxidant substances in the human body. This means that the presence of melatonin in the bloodstream helps to neutralize free radicals and inhibit the development of oxidative stress. It has also been extensively studied for its anti-inflammatory properties.1,2


Bioavailability of Melatonin

While melatonin provides the combined benefits of being a sleep support agent with potent antioxidant properties, there is some question as to whether or not these benefits can be properly harnessed when melatonin is ingested orally. The difficulty with capsule, liquid, or chewable varieties of melatonin supplements is that they must pass through the digestive system where much of their potency is degraded. In fact, the bioavailability of oral melatonin has been scientifically studied and shown to be particularly poor, especially in smaller doses.3

Suppository formulations of melatonin seem to be the most effective means for ensuring the absorption and utilization of this powerful nutrient. By releasing directly into the porous tissues of the lower bowel, suppositories bypass the digestive system entirely and arrive in the body undegraded. These particular suppositories are designed to melt and absorb quickly for convenience, but release the nutrients slowly over a period of 12 hours to ensure their full absorption and usefulness in the body.

Are the Suppositories Heat Sensitive?

The suppositories do not need to be refrigerated as heat will not affect their quality or potency. The suppository base is a superior form that uses an inclusion formula with heat stable ingredients. Nonetheless, we do give the option of purchasing ice, as some customers prefer it that way. Refrigeration is for "hardening" the suppository to facilitate insertion.


Supplement Facts

Serving Size: 1 suppository
Servings Per Container: 30

Amount Per Serving

Melatonin

200 mg

Suppository Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives.

Other Ingredients: This product contains an extract from soybean.


Dosage and Use:

  • 1 in the early evening 2 hours before bedtime or as directed by your health care professional.
  • Some individuals become drowsy immediately and should adjust the time when they take the product accordingly.
  • This product’s potential therapeutic effect is best realized when taken overnight where the release time occurs over an 11 hour period of time. This allows Melatonin to be released into the blood stream and exert a safe, prolonged beneficial/therapeutic effect.
  • It is recommended that you always attempt to move your bowels prior to inserting the suppository(s) to avoid discharging of the suppository before the suppository can be totally absorbed.
  • It is recommended that the suppository be retained for approximately 6 hours to insure adequate absorption of the nutraceutical, herbal and nutrient ingredients contained herein. Therefor it is best when taken before bedtime.
  • To facilitate insertion it is recommended you moisten suppository with warm water.
  • If inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion.


Research Links:


References:

1. Melatonin Anti-Inflammitory Study
2. Melatonin Antioxidant Study
3. Oral Melatonin Bioavailability


* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.


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