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Life Extension Carnosine, 500 mg, 60 Vegetarian Capsules

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Life Extension Carnosine 500 mg prevents glycation in the cells to work as an antioxidant and deter the physical signs of aging. Promotes heart health, muscle health, and general well being.

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Description

Benefits of Life Extension Carnosine

  • Antioxidant
  • Prevents glycation
  • Anti-Aging
  • Promotes heart health

Carnosine levels decline with age. The combination of carnosine, benfotiamine (a fat soluble form of vitamin B1) & vitamin B1 included in Life Extension Super Carnosine provides a multifaceted, body-wide shield against increased aging caused by glycation.

Carnosine is a multifunctional dipeptide made up of the amino acids beta-alanine and L-histidine.58 It is found both in food and in the human body. Long-lived cells such as nerve cells (neurons) and muscle cells (myocytes) contain high levels of carnosine.58 Muscle levels of carnosine correlate with the maximum life spans of animals. Carnosine has a number of antioxidant properties and has been shown to be an anti-glycating agent.59-65

This nutrient has the ability to suppress formation of advanced glycation end products (AGEs) and reactive oxygen species (ROS),66-69 culprits in metabolic dysfunction and oxidative stress that can lead to age-related conditions.70-72 Carnosine levels decline with age. Muscle levels decline 63% from age 10 to age 70, which may account for the normal age-related decline in muscle mass and function.73

Since carnosine acts as a pH buffer, it can keep on protecting muscle cell membranes from oxidation under the acidic conditions of muscular exertion. Carnosine enables the heart muscle to contract more efficiently through enhancement of calcium response in heart myocytes.74

Aging causes irreversible damage to the body’s proteins. One underlying mechanism behind this damage is glycation. Glycation involves the non-enzyme controlled cross-linking of proteins or lipids and sugars to form non-functioning structures in the body. The process of glycation can be superficially seen as wrinkled skin. Glycation is also an underlying cause of age-related neurologic, vascular, and eye problems.75-86 Carnosine is a unique dipeptide that can interfere with the glycation process.59-65

 

Supplement Facts

Serving Size: 1 vegetarian capsule

Servings Per Container: 60

Amount Per Serving

L-Carnosine

500 mg

Other Ingredients: vegetable cellulose (capsule), microcrystalline cellulose, stearic acid, silica.

Non-GMO

Dosage and Use:

  • Take one (1) capsule once or twice daily with or without food, or as recommended by a healthcare practitioner.

Warnings:

  • If pregnant, nursing, or taking medication, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

References:

1. Antioxidant activity of carnosine, homocarnosine, and anserine present in muscle and brain.
2. Carnosine as a natural antioxidant and geroprotector: from molecular mechanisms to clinical trials.
58. Biogerontology. 2007 Apr;8(2):129-37.
59. Arch Biochem Biophys. 2004 Jul 1;427(1):110-5.
60. Exp Gerontol. 2009 Apr;44(4):237-42. Epub 2008 Nov 11.
61. Ann N Y Acad Sci. 2002 Apr;959:285-94.
62. Biosci BiotechnolBiochem. 2002 Jan;66(1):36-43.
63. Nephron Clin Pract. 2007;107(1):c26-34.
64. Perit Dial Int. 2007 Jan-Feb;27(1):86-9.
65. Ann N Y Acad Sci. 2006 May;1067:369-74.
66. Protein J. 2011 Mar;30(3):149-58.
67. Acta Biol Hung. 2009 Jun;60(2):137-48.
68. Front Aging Neurosci. 2010 Mar 18;2:10.
69. Free Radic Biol Med. 2010 Mar 1;48(5):727-35.
70. Biochim Biophys Acta. 2009 May;1792(5):432-43.
71. J Alzheimers Dis. 2009;16(4):859-64.
72. Life Sci. 2002 Mar 1;70(15):1789-99.
73. Arch Gerontol Geriatr. 1999 Sep-Oct;29(2):107-13.
74. Am J Physiol. 1997 Jan;272(1 Pt 2):H462-8.
75. Diabetologia. 2002 Oct;45(10):1457-62.
76. Pathol Biol (Paris). 2003 Dec;51(10):543-9.
77. Brain Res Brain Res Rev. 2003 Mar;41(2-3):306-23.
78. Arthritis Rheum. 2004 Apr;50(4):1207-15.
79. Med Hypotheses. 2004;62(2):275-9.
80. Can J Physiol Pharmacol. 2000 Oct;78(10):848-55.
81. Ann N Y Acad Sci. 2001 Apr;928:48-53.
82. Arthritis Rheum. 2002 Jan;46(1):114-23.
83. J InvestDermatol. 2002 Aug;119(2):489-98.
84. Kurume Med J.2002;49(1-2):7-13.
85. Curr Pharm Des. 2008;14(10):946-52.
86. Metabolism. 2008 Oct;57(10):1452-7.

 

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

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