Zetpil Leucine with HMB Suppositories, 60 Count

Our Price: $99.00$105.95

To support muscles mass one needs to sustain a healthy workout routine and proper dietary intake. These suppositories contain a highly absorbable form of branched-chain amino acid, Leucine – an essential nutrient used in protein synthesis.

This product has been discontinued. We apologize for any inconvenience and recommend Zetpil BCAA Suppositories as a replacement.

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If muscle protein breakdown occurs at a faster rate than protein synthesis, muscles will become soft, saggy, and less functional. To support muscle mass one needs to sustain a healthy workout routine and proper dietary intake. Zetpil Leucine with HMB Suppositories contain a highly absorbable form of branched-chain amino acid, Leucine – an essential nutrient used in protein synthesis in muscles throughout the body.

  • Contains essential branched-chain amino acid, Leucine, and one of its metabolites, Calcium Hydroxymethybutyrate (HMB)
  • Provides nutritional support of muscle protein synthesis
  • Designed for those engaged in diet and exercise routines with the intent of building or maintaining muscle mass
  • Highly absorbable suppository formula helps to deliver nutrients where they are most needed and useful to the body
  • Suppositories can be shipped with ice to ensure preservation of shape and potency.

Understanding Muscle Catabolism and How to Prevent it

Muscle catabolism refers to the process of muscle tissues breaking down into smaller and more loosely bound segments. This causes muscles to develop a soft, sagging appearance. It also reduces their functionality. Muscle catabolism occurs for a number of reasons: advanced age, lack of exercise, or nutrient deficiencies. We can’t stop you from aging, or force you to go to the gym, but we can provide some essential nutrients your body needs to support a healthy muscle mass!

Branched-chain Amino Acids, Protein Synthesis, and Healthy Muscle Mass

Branched-chain amino acids are essential nutrients. This means that they can’t be produced in the body, so they are most commonly obtained from breaking down proteins in the foods we eat. After being broken down and absorbed in the digestive system, branched-chain aminos play a pivotal role in protein synthesis in muscles throughout the body. Leucine is one of the most primary of these branched-chain aminos.

In order for muscle mass to be developed and retained, protein synthesis must exceed protein breakdown.1 With age, our bodies tend to suffer losses in their ability to synthesize protein, and muscle catabolism occurs at accelerated rates. Often times, nutritional deficiencies play a significant role in this process as well. These suppositories contain branched-chain amino acid, Leucine, and one of its metabolites, Calcium Hydroxymethybutyrate (HMB). Both substances play a supportive role in healthy protein synthesis.2,3



Note: Storing this product at room temperature will not alter the effectiveness or potency. However a firm suppository is necessary for a comfortable and easy insertion. Therefore we recommend that this product be stored in the refrigerator to maintain firmness. If the suppository does become soft, place the suppository in the refrigerator to achieve the firmness needed for comfortable insertion Avoid excessive heat 40°C (104°F). Store in a cool place 8° to 15°C (46° to 59°F) or refrigerate. When using nutritional supplements or nutraceuticals, please inform your physician if you are undergoing treatment for a medical condition healthcare professional.


  • If pregnant, nursing, or undergoing treatment for a medical condition, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.



Supplement Facts

Serving Size: 1 suppository
Servings Per Container: 60

Amount Per Serving

Proprietary blend of Leucine and Calcium Hydroxymethybutyrate (Calcium HMB)


Suppository Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, guargum and xanthan gum.

Other Ingredients: This product contains an extract from soybeans. This product contains NO milk, egg. fish, peanuts, crustacean (lobster, crab. & Shrimp), tree nuts. wheat, yeast, corn, rice, sugar, preservatives or hydrogenated oils.


Dosage & Use

Click to view detailed instructions on How to Insert Suppositories.

  • It is recommended that you always attempt to move your bowels prior to inserting the suppository(s) to avoid discharging of the suppository before the suppository can be totally absorbed.
  • It is recommended that the suppository be retained for approximately 10 (ten) minutes to insure adequate absorption of the ingredients contained herein.
  • To facilitate insertion it is recommended you moisten suppository with cool water.
  • If inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion.


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1. Protein metabolism
2. Leucine
3. HMB