Thorne Research Perma-Clear, Aid for Leaky Gut and Digestive Health, 180 Capsules

List Price: $80.00
Our Price: $76.00

Perma-Clear from Thorne Research contains a unique and potent blend of digestive support ingredients including l-glutamine, n-acetyl glucosamine, and probiotics. May help to relieve gastrointestinal conditions like bloating, excessive gas, and cramps.

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Those who experience symptoms associated with ‘leaky gut syndrome’, or other forms of gastrointestinal discomfort that involve bloating, excessive gas, and cramps, may find the answer to these problems lies in their dietary choices. Perma-Clear from Thorne Research contains a unique and potent blend of digestive support ingredients including l-glutamine, n-acetyl glucosamine, and probiotics.

  • Designed to help you maintain the durability of the intestinal lining.
  • L-glutamine may aid in healthy tight junction proteins.
  • N-acetyl glucosamine supports the health of epithelial cells.
  • Includes probiotics bacillus coagulans, bifidobacterium bifidum, and saccharomyces boulardii.

Understanding ‘Leaky Gut Syndrome’

Leaky gut syndrome is more of a catch-all term than any particular kind of disease or malady. In fact, we all have leaky guts to one degree or another. This is because the intestinal lining – a thin surface which covers 4000 square feet of the gut, and regulates what passes from the digestive tract into the bloodstream – is a permeable barrier by design.

The term ‘leaky gut syndrome’ is often applied to a set of conditions which indicate that the gut lining may have cracks and holes which expand its permeability to an unhealthy extent, allowing partially digested food, toxins, and bugs to penetrate it. This often results in feelings of bloatedness, gas, cramps, and other irritations. It can also have serious long-term consequences for the health of the gut.1

How to Nutritionally Support Digestive Health

There are a number of nutritional compounds which may be added to one’s dietary intake as a means of supporting the healthy permeability of the intestinal lining, alongside other significant benefits for the digestive system. Some of the most popular and widely researched of these include l-glutamine, n-acetyl glucosamine, and probiotics like bacillus coagulans and saccharomyces boulardii.

L-glutamine is an amino acid which is uniquely involved in the healthy function of the gastrointestinal tract. It may be particularly helpful among other aminos for supporting healthy gut physiology by way of regulating tight junction proteins along the intestinal lining, suppressing pro-inflammatory signaling pathways, and protecting cells against apoptosis and cellular stresses.2

Meanwhile, n-acetyl glucosamine is a chemical compound found in shellfish which is thought to be particularly useful for supporting the health of the epithelial cells which make-up the entirety of the digestive tract.3

‘Probiotic’ generally is used to refer to any microbial organism which, as opposed to microbial viruses, parasites, and other infections, provide positive effects for the health of the human body. There are countless varieties of probiotics which may in turn provide support for a variety of bodily systems and functions. However, they are best known for the multitude of benefits they can provide for a health gastrointestinal tract by way of balancing the flora of bacteria in the gut. Some studies have shown that probiotics may aid in synthesis and assembly of tight junction proteins and protection of those same tight junctions and other barriers in the endothelial lining.4


Caution: Contains ingredient derived from shellfish (N-Acetylglucosamine = crab and/or shrimp).


  • If pregnant, nursing, or undergoing treatment for a medical condition, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.


Supplement Facts

Supplement Facts

Serving Size: 3 Capsules

Servings Per Container: 60

Amount Per Serving
L-Glutamine 900 mg
N-Acetylglucosamine 750 mg
Saccharomyces boulardii 112.5 mg
Quercetin Phytosome (Sophora japonica concentrate (leaf) / Phosphatidylcholine complex from Sunflower) 112.5 mg
Bacillus coagulans* 75 mg
Ginger extract (root, rhizome) (Zingiber officinale) 30 mg
Other Ingredients: Hypromellose (derived from cellulose) capsule, Silicon Dioxide.

Dosage & Use

  • Take 3 capsules two times daily or as recommended by your health professional.


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1. Leaky Gut Syndrome Information
2. L-Glutamine Review
3. N-Acetyl Glucosamine Review
4. Probiotics Review