Benefits of Super-Absorbable CoQ10 Ubiquinone with d-Limonene
- Supports heart health
- Helps reduce the physical effects of aging
- Protects cells from oxidative stress and damage
- Strengthens the immune system
- Reduces occurrence of migraine headaches
- Supports visual health
Life Extension’s Super Absorbable CoQ10 with d-Limonene provides the ubiquinone form of Q10 in a super-emulsified formulation that increases the amount of coenzyme Q10 absorbed. Supports heart, aging, oxidation, vision, the immune system and much more.
The mitochondria are the cells’ energy powerhouses, and coenzyme Q10 (CoQ10) is an essential component of healthy mitochondrial function.30 CoQ10 is required to convert the energy from fats and sugars into usable cellular energy. Yet, the body’s production of CoQ10 declines significantly with advancing age.31 With an ample amount of CoQ10, mitochondria can work most efficiently throughout the entire body – including the most densely populated area, the heart.32 CoQ10 is also a potent antioxidant, helping protect proteins, and DNA of mitochondria from oxidation and supporting mitochondrial function.30
More people are supplementing with CoQ10 than ever before. One reason is increased awareness that “statin” drugs used to lower LDL and cholesterol deplete CoQ10 levels in the blood, and possibly the tissues.33,34
What most doctors don’t know, however, is that normal aging may result in more of a reduction in CoQ10 than taking statins. For example, while statin drugs have been shown to reduce plasma CoQ10 by nearly 40%,35 the aging process reduces CoQ10 levels in the heart muscle wall by 72%.36 What is particularly frightening is the deficit caused by the dual effects of aging and statin drug use that can result in severe depletion of cellular vitality.35
Over the past 30 years Q10 (CoQ10) has had hundreds of published and peer-reviewed studies demonstrating its ability to protect heart health.1 New research has suggested CoQ10 may also offer other important benefits. Studies indicate it may:
- Protect against photo-aging and melanoma2-4
- Help to delay or avert breast and prostate cancers1,5-7
- Improve blood sugar control in diabetics8,9
- Support endothelial dysfunction10-12
- Slow the progression of Parkinson’s and other neurodegenerative diseases13-15
- Help reduce the amount of migraine headaches16,17
- Support the immune system10,18-20
- Help with visual health including age-related macular degeneration21,22
- Prevent periodontal disease1,10
- Improve male fertility10,27,28
CoQ10 is essential for all cells to function properly. Because of that, may different conditions and diseases are positively affected by supplementation. Coenzyme Q10 may be as important as vitamin C to maintaining good health and combating the effects of aging.29
d-Limonene is a natural compound in orange oil that disperses and breaks down the CoQ10 particles, which reduces their size and makes CoQ10 more absorbable by the body.
Serving Size: 1 softgel
Servings Per Container: 60
Amount Per Serving
d-Limonene [cold-pressed orange oil (peel)]
Ubiquinone (as Kaneka Q10®)
Other Ingredients: polysorbate 80, gelatin, ethyl oleate, glycerin, purified water, carob color, d-alpha tocopherol, rosemary extract.
Kaneka Q10® is a registered trademark of Kaneka Corporation.
Dosage and Use:
- Take one softgel daily with food, or as recommended by a healthcare practitioner.
- If pregnant, nursing, or taking medication, consult your physician before taking this product
- Keep out of reach of children
- Do not exceed recommended dose
1. Horowitz S. Coenzyme Q10: one antioxidant, many promising implications. Altern Comp Therapies. 2003 Jun:111-6.
2. Rusciani L, Proietti I, Rusciani A, et al. Low plasma coenzyme Q10 levels as an independent prognostic factor for melanoma progression. J Am Acad Dermatol. 2006 Feb;54(2):234-41.
3. Hoppe U, Bergemann J, Diembeck W, et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9(2-4):371-8.
4. Available at: www.new-chapter.com/research/coq10_skin.html. Accessed May 22, 2006.
5. Quiles JL, Farquharson AJ, Ramirez-Tortosa MC, et al. Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells. Biofactors. 2003;18(1-4):265-70.
6. Folkers K, Wolaniuk A. Research on coenzyme Q10 in clinical medicine and in immunomodulation. Drugs Exp Clin Res. 1985;11(8):539-45.
7. Available at: www.bccancer.bc.ca/PPI/UnconventionalTherapies/CoenzymeQUbiquinone.htm. Accessed May 22, 2006.
8. Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves blood pressure and glycaemic control in a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42.
9. Gaby AR. The role of coenzyme Q10 in clinical medicine: Part II. Cardiovascular disease, hypertension, diabetes mellitus and infertility. Altern Med Rev. 2001 Sept;1(3):168-75.
10. [No authors listed] Coenzyme Q10. Altern Med Rev. 1998 Feb;3(1):58-61.
11. Kuettner A, Pieper A, Koch J, Enzmann F, Schroeder S. Influence of coenzyme Q(10) and cerivastatin on the flow-mediated vasodilation of the brachial artery: results of the ENDOACT study. Int J Cardiol. 2005 Feb 28;98(3):413-9.
12. Langsjoen H, Langsjoen P, Langsjoen P, Willis R, Folkers K. Usefulness of coenzyme Q10 in clinical cardiology: a long-term study. Mol Aspects Med. 1994;15 Suppls165-75.
13. Shults CW, Oakes D, Kieburtz K, et al. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002 Oct;59(10):1541-50.
14. Beal MF. Mitochondrial dysfunction and oxidative damage in Alzheimer’s and Parkinson’s diseases and coenzyme Q10 as a potential treatment. J Bioenerg Biomembr. 2004 Aug;36(4):381-6.
15. Baker SK, Tarnopolsky MA. Targeting cellular energy production in neurological disorders. Expert Opin Investig Drugs. 2003 Oct;12(10):1655-79.
16. Rozen TD, Oshinksy ML, Gebeline CA, et al. Open label trial of coenzyme Q10 as a migraine preventive. Cephalgia. 2002 Mar;22(2):137-41.
17. Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology. 2005 Feb 22;64(4):713-5.
18. Gazdik F, Gvozdjakova A, Nadvornikova R, et al. Decreased levels of coenzyme Q(10) in patients with bronchial asthma. Allergy. 2002 Sep;57(9):811-4.
19. Ye CQ, Folkers K, Tamagawa H, Pfeiffer C. A modified determination of coenzyme Q10 in human blood and CoQ10 blood levels in diverse patients with allergies. Biofactors. 1988 Dec;1(4):303-6.
20. Rosenfeldt FL, Mijch A, McCrystal G, et al. Skeletal myopathy associated with nucleoside reverse transcriptase inhibitor therapy: potential benefit of coenzyme Q10 therapy. Int J STD AIDS. 2005 Dec;16(12):827-9.
21. Blasi MA, Bovina C, Carella G, et al. Does coenzyme Q10 play a role in opposing oxidative stress in patients with age-related macular degeneration? Opthalmologica. 2001 Jan-Feb;215(1):51-4.
22. Feher J, Kovacs B, Kovacs I, Schveoller M, Papale A, Balacco Gabrieli C. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10. Opthalmologica. 2005 May-Jun;219(3):154-66.
23. Available at: www.kanekaq10.com. Accessed May 22, 2006.
24. Schrier T. Kaneka Nutrients LP. Email interview. April 25, 2006.
25. Ikematsu H, Nakamura K, Harashima S, Fujii K, Fukutomi N. Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol. 2006 Apr;44(3):212-8.
26. Available at: www.nutraingredients.com/news/ng.asp?id=65767-kaneka-coq. Accessed May 22, 2006.
27. Sheweita SA, Tilmisany AM, Al-Sawaf H. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab. 2005 Oct;6(5):495-501.
28. Balercia G, Mosca F, Mantero F, et al. Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004 Jan;81(1):93-8.
29. Available at: http://faculty.washington.edu/ely/coenzq10.html. Accessed May 22, 2006.
30. Mol Biotechnol. 2007 Sep;37(1):31-7.
31. Mech Ageing Dev. 2010 Apr;131(4):225-35.
32. Biofactors. 2003;18(1-4):91-100.
33. Mitochondrion. 2007 Jun;7 Suppl:S168-74.
34. Cardiol Rev. 2005 Mar-Apr;13(2):76-9.
35. J Clin Pharmacol. 1993 Mar;33(3):226-9.
36. Biofactors. 1999;9(2-4):291-9
38. National Cancer Institute: Coenzyme Q10
* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.