Pure Encapsulations Alpha Lipoic Acid with GlucoPhenol contains powerful antioxidants and polyphenols to support blood glucose and fat metabolism, endothelial dilation, inflammation and the cardiovascular system. Offers outstanding cardiometabolic health.
Over the past decade, research in metabolism and cardiology has highlighted important links between metabolic and cardiovascular health. Accordingly, highly effective therapeutic approaches to glucose homeostasis, lipid metabolism and vascular health address the larger picture of “cardiometabolic health.” Recent cross-disciplinary studies have established that maintaining inflammatory balance in the liver, muscle, fat and vascular endothelium is a powerful approach to optimizing and sustaining cardiometabolic health.
Alpha lipoic acid
Alpha lipoic acid is a multifaceted nutraceutical substantiated by over 15 years of clinical research. In a recent double-blind, placebo-controlled trial, daily alpha lipoic acid supplementation provided statistically significant support for both fasting and postprandial blood glucose.1 In a randomized placebo-controlled study, alpha lipoic acid supported healthy endothelial dilation, an important measure of cardiovascular health.2
By maintaining healthy activity of the genomic inflammatory messenger nuclear factor kappa B (NFκB), alpha lipoic acid helps maintain the ability of cells to utilize glucose.3 In addition, alpha lipoic acid promotes the activity of PGC-1α and AMP kinase (AMPK), two critical regulators of mitochondrial function.4 By supporting the synthesis of new mitochondria, alpha lipoic acid enhances the ability of the cell to metabolize both carbohydrates and fats (Figure 1).5 These actions are associated with metabolic homeostasis in fat, liver, muscle and vascular tissue.
Alpha-lipoic acid is an antioxidant that is both fat- and water-soluble. This means it isn’t limited to certain areas of the body like other antioxidants. Research indicates that alpha lipoic acid actually helps replenish other antioxidants.10
GlucoPhenol: Combined cardiovascular and metabolic benefits
GlucoPhenol delivers 25 mg of polyphenols from a unique blend of cranberry and Orléans strawberry standardized extracts. Polyphenols in cranberry and strawberry target cellular metabolic paradigms that overlap and complement well-established mechanisms of alpha lipoic acid. Cranberries, which contain the highest level of total phenolics of all common fruits, are rich in polyphenol oligomers known as proanthocyanidins (PAC). Known as A-type PAC, these rare phenolics differ from those in tea, cocoa and grapes, and mediate many of the effects of cranberries on metabolism and vascular tissue. Although lower in total polyphenols, strawberries exhibit a unique profile of phenolics, including anthocyanins, quercetin, ellagic acid and catechin. Both fruits support the function of enzymes, receptors and genes involved in glucose uptake and cytokine signaling.6 Specifically, both PAC and low-molecular weight phenolics maintain inflammatory balance by targeting NFκB (Figure 1).7 This genomic factor regulates genes involved in both inflammatory and glycemic responses. Scientists attribute the successful cardiometabolic outcomes in clinical research to inflammatory balance achieved through gene expression.
Alpha Lipoic Acid w/GlucoPhenol
Science-based approach to cardiometabolic health
- Delivers 200 mg alpha lipoic acid per serving for metabolic support and cardioprotection
- Provides 25 mg polyphenols per serving from GlucoPhenol, a novel, proprietary extract of cranberry and Orléans strawberry developed and studied as part of a research collaboration with the Institute of Nutraceuticals and Functional Foods (INAF)
- Supports healthy glucose and fat metabolism by targeting cellular receptors and cellular mediators
- Supports overall cardiometabolic health by maintaining inflammatory balance and vascular health
Serving Size: 1 vegetarian capsule
Servings Per Container: 120
Amount Per Serving
alpha lipoic acid (thioctic acid)
GlucoPhenol proprietary blend:
25 mg of polyphenols from Orléans strawberry (Fragaria vesca var Orléans) extract (fruit) and cranberry (Vaccinium macrocarpon) extract (fruit)
Other Ingredients: hypoallergenic plant fiber (cellulose), ascorbyl palmitate, rice maltodextrin, silicon dioxide, vegetarian capsule (cellulose, water)
Dosage and Use:
- 1–4 capsules per day, in divided doses, with meals.
Note: Alpha lipoic acid has been associated with gastrointestinal upset or skin rash in sensitive individuals. Consult your physician for more information.
Caution: Individuals on anti-diabetes medications may require blood glucose monitoring. Consult your physician for more information.
- If pregnant, nursing, or undergoing treatment for a medical condition, consult your physician before taking this product
- Keep out of reach of children
- Do not exceed recommended dose
1. Xiang GD, Sun HL, Zhao LS, Hou J, Yue L, Xu L. The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance. Clin Endocrinol (Oxf) (2008)68(5):716-23.
2. Heinisch BB, Francesconi M, Mittermayer F, Schaller G, Gouya G, Wolzt M, Pleiner J. Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. Eur J Clin Invest (2010) 40(2):148-54.
3. Packer L, Cadenas E. Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling. J Clin Biochem Nutr (2011) 48(1):26-32.
4. Salminen A, Hyttinen JM, Kaarniranta K. AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan. J Mol Med (Berl) (2011) 89(7):667-76.
5. Wang Y, Li X, Guo Y, Chan L, Guan X. Alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor- gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism (2010) 59(7):967-76.
6. Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D. Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res (2007) 51(6):675-83.
7. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res. (2001) Sep 1;480-481:243-68.
8. Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr (2006) 15(3):433-41.
9. Lee IT, Chan YC, Lin CW, Lee WJ, Sheu WH. Effect of cranberry extracts on lipid profiles in subjects with Type 2 diabetes. Diabet Med (2008) 25(12):1473-7.
10. University of Maryland Medical Center: Alpha-lipoic acid
11. Alpha-lipoic acid supplementation and diabetes.
* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.