Ortho Molecular Products Methyl CpG, B Vitamins for Methylation Support, 60 Capsules

Our Price: $40.80

Those who are serious about supporting healthy methylation and homocysteine levels know that a couple of folate capsules won’t quite do the trick. That’s why Ortho Molecular Products has crafted Methyl CpG: to bring you the best in methyl support supplementation. Contains all the B-complex vitamins needed for healthy DNA methylation and homocysteine balance.

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  • Features potent doses of folate (in the form of 5-Methyltetrahydrofolic acid glucosamine salt), riboflavin (vitamin B2), pyridoxine (vitamin B6), and vitamin B12.
  • Designed for optimal methylation and homocysteine balance support.
  • May aid in cardiovascular health.
  • Formulated to be free of allergens derived from: Gluten, corn, yeast, artificial colors and flavors.
  • 60 natural vegetable capsules per container.

Methylation, Homocysteine & Human Health

Homocysteine, methylation. methyl cpg, amino acid

Homocysteine amino acid molecule.

DNA methylation occurs in all mammals. It is a multifaceted process with countless health ramifications, but it all boils down to this: methylation enables gene regulation and development by adding methyl groups to certain DNA molecules. Without DNA methylation, countless physiological systems and processes would malfunction, and the body would be more susceptible to the development of certain severe health concerns.1

Homocysteine is an amino acid which is released as a byproduct of methylation. Elevated homocysteine levels are associated with cardiovascular health risks.2 Thankfully, balanced DNA methylation and homocysteine levels have a lot in common. In particular, they both hinge upon the presence of B-complex vitamins in the body.

B-Complex Vitamins & Methylation

Folate (sometimes known as vitamin B9), riboflavin (vitamin B2), pyridoxine (vitamin B6), and vitamin B12 all have a role in methyl group metabolism and DNA methylation.3 They achieve this by serving as cofactors in enzymatic reactions which are integral to the methylation process.

It is widely thought that folate has the most direct effect on methylation. This is a reasonable conclusion to draw given the body of evidence which associates low folate levels with decreased DNA methylation.4 However, there is still much to be discovered about this relationship.

It is currently unclear if folate levels have a significant impact on every genome region, or even if increased folate or folic acid consumption actually has a direct impact on methylation.4 For these reasons, it is important not to limit oneself to folate alone when attempting to nutritionally bolster DNA methylation.

Thankfully, Ortho Molecular Products Methyl CpG contains all of the B-complex vitamins which are associated with healthy methylation. These powerful ingredients are dosed according to scientific standards and delivered in natural vegetable capsules. This level of attention to detail is what puts Ortho-Molecular ahead of the curve.



  • If pregnant, nursing, or undergoing treatment for a medical condition, consult your physician before taking this product.
  • Keep out of reach of children.
  • Do not exceed recommended dose.

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

Supplement Facts

Serving Size: 1 Capsule

Servings Per Container: 60

Amount Per Serving

Riboflavin (Vitamin B2 USP)

25 mg

Vitamin B6 (as Pyridoxine Hydrochloride USP)

50 mg

Folate 2,000 (6S)-5-Methyltetrahydrofolic acid glucosamine salt)

2000 mcg

Vitamin B12 (as Methylcobalamin)

1000 mcg

Betaine (Trimethylglycine)

500 mg

Other Ingredients: Natural Vegetable Capsules, Microcrystalline Cellulose, Magnesium Stearate, Stearic Acid, Calcium Silicate, Silicon Dioxide

Dosage & Use

  • 1 capsule per day or as recommended by your health care professional.


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  1. DNA Methylation
  2. Methylation demand: a key determinant of homocysteine metabolism.
  3. DNA Methylation Variants at HIF3A Locus, B-Vitamin Intake, and Long-term Weight Change: Gene-Diet Interactions in Two U.S. Cohorts
  4. Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate’s Role