Ortho Molecular Product AdreneVive, HPA Axis Support, 60 Capsules

Our Price: $53.00

Stress isn’t just a state of mind. It has a physical impact on the body and can do serious long-term damage to your health if left unchecked. Ortho Molecular Products AdreneVive is ideal for those with highly stressful lifestyles, or anyone looking to support their hypothalamic-pituitary-adrenal (HPA) axis.

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  • A one-of-a-kind blend featuring ashwagandha, rhodiola rosea, eleuthero (Siberian ginseng), skullcap root, l-theanine, and phosphatidylserine.
  • Adaptogen content may aid in a healthy stress response.
  • Designed for comprehensive HPA axis support.
  • May have an impact on energy, focus, and sleep.
  • 60 natural vegetable capsules.

Stress & Human Health

Everyone is familiar with stress. Whether it’s the traffic on your morning commute, a long night of studying for a difficult exam, or even just general feelings of anxiety over future goals and plans – stress is an inevitable part of our day-to-day lifestyles. That isn’t even to mention all of the potential stressors that are lurking in our environment.

The body has an elaborate stress response system which goes through a number of different phases depending upon the particular stressor. The entirety of the system is based in the hypothalamic-pituitary-adrenal (HPA) axis – a trifecta of glands whose interactions play a key role in the regulation of stress response, digestion, the immune system, and even mood.1

While stress is a natural part of life, excessive stress response can generate short and long-term health complications. Many of these complications arise as a result of imbalances in hormones like cortisol and DHEA which are secreted from the adrenal gland (the ‘A’ in HPA axis). Due to the inevitability of day-to-day stressors, many health experts are left questioning the best ways to nutritionally support the body’s innate stress response system, as well as the HPA axis in general. Ortho-Molecular has done extensive research in this field as well. AdreneVive is the product of their research and careful attention to detail.

Ingredients for Stress Response & HPA Axis Support

Powdered ashwagandha roots, also known as Indian ginseng, is one of the most popular adaptogenic herbal extracts.

Adaptogenic Herbs – an ‘adaptogen’ is any plant compound which may help the body to adapt to stressful situations via the central nervous system.2 Much is left to be researched about many of these compounds, but adaptogenic herbs do serve as a useful classification for those seeking nutritional HPA axis support. Ortho Molecular Products AdreneVive contains a number of the most notorious adaptogenic herbal extracts such as ashwagandha, rhodiola rosea, and eleuthero (siberian ginseng).

L-Theanine – this amino acid is primarily found in tea leaves and may serve as the primary reason that green tea in particular is often consumed for its soothing qualities. One double-blind, placebo-controlled study using 200 mg of l-theanine found that “subjective stress response to a cognitive stressor was found to be significantly reduced one hour post-dose, and cortisol response was significantly reduced three hours post-dose”.3

Phosphatidylserine – a phospholipid that is commonly found in the human brain. Phosphatidylserine has been found to support multiple aspects of cognitive function, most relevant to the HPA axis being its use in the formation of nerve cell membranes. Additionally, is absorbed efficiently in humans and crosses the blood-brain barrier.4



  • If pregnant or lactating, consult your physician before taking this product.
  • Keep out of reach of children.
  • Do not exceed recommended dose.


* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease

Supplement Facts

Serving Size: 2 Capsules

Servings Per Container: 30

Amount Per Serving

Ashwagandha Root Extract (Standardized to contain 1.5% Withanolides)

250 mg

Skullcap Root Extract (Standardized to contain 30% Flavones as S. baicalensis)

250 mg

Eleuthero Root Extract (Standardized to contain 0.8% Eleutherosides)

200 mg

Rhodiola rosea Root Extract (Standardized to contain 3% Rosavins)

200 mg


100 mg

Phosphatidylserine (from Soy Lecithin)

100 mg

Other Ingredients: Natural Vegetable Capsules, Magnesium Stearate, Calcium Silicate, and Stearic Acid.

Contains Soy.

Dosage & Use

  • 2 capsules taken one to two times per day or as recommended by your health care professional.


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  1. HPA Syndrome – Cortisol and DHEA – Examples of Importance
  2. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity
  3. Anti-Stress, Behavioural and Magnetoencephalography Effects of an l-Theanine-Based Nutrient Drink: A Randomised, Double-Blind, Placebo-Controlled, Crossover Trial
  4. Phosphatidylserine and the human brain.