Life Extension TMG (Trimethylglycine), Liquid Vegetarian Capsules or Powder

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TMG is a cofactor in methylation. This process has been shown to reduce homocysteine levels and raise methionine levels. Trimethylglycene helps synthesize serotonin and melatonin, raises SAMe levels and supports nonalcoholic fatty liver disease.

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Description

TMG is a cofactor in methylation. This process has been shown to reduce homocysteine levels and raise methionine levels. Trimethylglycene helps synthesize serotonin and melatonin,1 raises SAMe levels and supports nonalcoholic fatty liver disease.2

During the 1950s, Trimethylglycine (TMG or glycine betaine) was found to support heart health.146-150 TMG supports the reduction of homocysteine and the increase of methionine.151-153 Excess homocysteine levels don’t only affect the cardiovascular system. Additional symptoms may include3

  • Extreme tiredness
  • Osteoporosis
  • Blood clots
  • Seizures
  • Abnormal bone structure

Studies suggest that TMG may benefit those with Nonalcoholic Fatty Liver Disease. One human study done at the Mayo Clinic reported improvement in steatosis, inflammation and fibrosis.2

 

Supplement Facts

Serving Size: 2 vegetarian liquid capsules

Servings Per Container: 30

Amount Per Serving

Trimethylglycine (TMG) (as betaine anhydrous)

1000 mg

Other Ingredients: glycerin, vegetable cellulose (capsule), purified water.

Dosage and Use:

  • Take two tablets in the morning with or without food, or as recommended by a healthcare practitioner.
  • TMG should be taken with co-factors vitamins B6, B12, and folic acid.

Caution: If muscle tension or headaches occur, reduce dose or discontinue product, and inform your physician if they do not subside.

Warnings:

  • If pregnant, nursing, or taking medication, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

References:

1. Wikipedia: Trimethylglycine
2. Treatment Options for Nonalcoholic Fatty Liver Disease
3. MedlinePlus: Betaine
105. Ann West Med Surg. 1951;5:825-9.
106. Ann West Med Surg. 1951;5:830-55.
107. Ann West Med Surg. 1951;5:856-62.
108. JAMA. 1951;145:1232-6.
109. Am J Dig Dis. 1952;19:381-4.
110. Mol Genet Metab. 2006 Jul;88(3):201-7.
111. Biochemistry. 1999 Oct 19;38(42):13991-8.
112. Greene, R. C. 1996. Biosynthesis of methionine, p. 542-560. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed. ASM Press, Washington, DC.
113. J Nutr. 2003 Dec;133(12):4135-8.
114. J Nutr. 2003 May;133(5):1291-5.
115. Am J Clin Nutr. 2002 Nov;76(5):961-7.
116.. Br J Clin Pharmacol. 2002 Aug;54(2):140-6.
117. Kidney Int. 2002 Mar;61(3):1040-6.
118. An Esp Pediatr. 1993 Jul;39(1):37-41.
119. Metabolism. 1985 Dec;34(12):1115-21.
120. N Engl J Med. 1983 Aug 25;309(8):448-53.
121. J Nutr. 2006 Jan;136(1):34-8.
122. Am J Clin Nutr. 2008;87:424–30.

 

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

 

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