Life Extension SAMe (S-Adenosyl-Methionine), 400 mg or 200 mg, Enteric Coated Tablets

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The U.S. Department of Health and Human Services evaluated SAMe in 2002. They found SAMe able to maintain a consistent mood and support joint comfort with no side effects. S-adenosylmethionine also supports the antioxidant glutathione and liver health.

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Description

Benefits of Life Extension SAMe (S-Adenosyl-Methionine)

  • Helps maintain a stable mood
  • Supports positive moods
  • Improves joint health and function
  • Supports liver health and function
  • Boosts natural antioxidants in the body
  • Causes no side effects

The U.S. Department of Health and Human Services evaluated SAMe in 2002. They found SAMe able to maintain a consistent mood and support joint comfort with no side effects. S-adenosyl-L-methionine also supports the antioxidant glutathione and liver health.

SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:

  • Methylation (contributing methyl groups to activate certain molecules)8,9
  • The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.)10-14
  • Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)15-17

SAMe occurs naturally in the body. It is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways.28 SAMe facilitates glutathione usage and maintains acetylcholine levels, which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.

SAMe levels may become depleted from sickness and age. Supplementation with the co-factors – folate, trimethylglycine (TMG or betaine), vitamins B6 and B12, together with SAMe – appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine.24-27

In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Its findings show the efficacy of SAMe in helping to maintain stable mood and joint function without any side effects.18 Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older.19-24 In addition, SAMe has multiple mechanisms of action that are used throughout the body, especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione.35 When liver function is compromised, glutathione is depleted, which leads to free radical damage.

 

Supplement Facts

Serving Size: 1 enteric coated tablet

Servings Per Container: 60 (30)

Amount Per Serving

S-Adenosyl-Methionine

400 mg (200 mg)

Other Ingredients: cellulose, methacrylic acid copolymer, mannitol, citric acid, titanium dioxide, stearic acid, silica, hydroxypropyl methylcellulose, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, yellow ochre.

Dosage and Use:

  • Take one tablet two to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid.

Caution: SAMe should not be taken by those diagnosed with bipolar disorder.

Warnings:

  • If pregnant, nursing, or taking medication, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

References:

1. S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease
2. Am J Clin Nutr. 2002 Nov;76(5):1151S-7S.
3. Psychiatr Pol. 2011 Nov-Dec;45(6):923-31.
4. Mol Cell Proteomics. 2012 Nov;11(11):1274-88.
5. Clin Chem Lab Med. 2013 Mar 1;51(3):457-65.
6. Toxicol Lett. 2012 Aug 3;212(3):320-8.
7. Phys Biol. 2008 Dec 19;5(4):044002.
8. J Nutr Health Aging. 2008 Apr;12(4):252-61.
9. Science. 2011 Apr 29;332(6029):604-7.
10. Pharmacol Biochem Behav. 2001 Sep;70(1):105-14.
11. Neuroreport. 2001 Dec 21;12(18):3939-42.
12. Drugs. 1994 Aug;48(2):137-52.
13. J Clin Psychiatry. 2009;70 Suppl 5:18-22.
14. J Cell Sci. 2014 Jan 1;127(Pt 1):50-9.
15. Clin Rev Allergy Immunol. 2012 Feb;42(1):58-70.
16. Toxicol Sci. 2010 May;115(1):131-9.
17. World J Gastroenterol. 2010 Mar 21;16(11):1366-76.
18. Am J Clin Nutr. 2002 Nov;76(5):1151S-7S.
19. Evidence Report/Technology Assessment: Number 64 S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease https://archive.ahrq.gov/clinic/epcsums/samesum.htm
19. Neuroreport. 2001 Dec 21;12(18):3939-42.
20. J Nutr Health Aging. 2008 Apr;12(4):252-61.
21. Proc Nutr Soc. 2011 Nov 4:1-9.
22. J Nutr Health Aging. 2010 Mar;14(3):224-30.
23. Vet Ther. 2008 Summer;9(2):69-82.
24. Metabolism. 2011 May;60(5):673-80.25.
25. Physiol Rev. 2012 Oct;92(4):1515-42.
26. Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G91-103.
27. Rocz Akad Med Bialymst. 2005;50:7-20.
28. World J Gastroenterol. 2006 Mar 28;12(12):1895-904.
29. J Inherit Metab Dis. 1991;14(4):421-30.
30. FASEB J. 1996 Mar;10(4):471-80.
31. Alcohol. 2002 Jul;27(3):179-83.
32. Minerva Gastroenterol Dietol. 1992 Jul-Sep;38(3):145-51.
33. Pharmacol Biochem Behav. 2001 Sep;70(1):105-14.
34. Am J Psychiatry. 2010 Aug;167(8):942-8.
35. Naunyn Schmiedebergs Artch Pharmacol. 2000 Jan; 361 (1): 47-52.

 

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

 

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