Life Extension MSM, 1000 mg, 100 Capsules

Our Price: $14.50

MSM (methylsulfonylmethane or dimethylsulfone) plays an important role in the health of our body’s joints, skin, hair, nails and cartilage. Research indicates relief from joint pain, an increased range of motion and protecting the muscles from damage.

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As people age, systemic inflammation can inflict degenerative effects throughout the body.1-5 A primary cause of this destructive cascade is the production of cell-signaling chemicals known as pro-inflammatory cytokines. Along with these dangerous cytokines, imbalances of hormone-like messengers called prostaglandins and leukotrienes also contribute to inflammatory processes.6-8

MSM (methylsulfonylmethane or dimethylsulfone) is a sulfur-containing molecule found in various plants and some body tissues.72-76 MSM is a vital building block of joints, cartilage, skin, hair and nails. It is a natural and efficient source of the sulfur that is used by many of the body’s structural molecules.76 Some peer-reviewed clinical research in the U.S. has shown MSM is safe and effective in increasing joint comfort and supporting a normal range of motion.77-82

MSM supplementation seems to help reduce symptoms of osteoarthritis, particularly in the knee.9 Clinical trials have shown patients that took MSM had a significant decrease in pain and improved physical function.10,11 Other studies found supplementation decreased muscle damage from exercise.12


Supplement Facts

Serving Size: 3 capsules

Servings Per Container: 33

Amount Per Serving
Methylsulfonylmethane 3000 mg
Other Ingredients: gelatin, vegetable stearate.
This product contains NO: milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

Dosage and Use:

  • Take three capsules once or twice daily with or without food, or as directed by a healthcare practitioner.


  • If pregnant, nursing, or taking medication, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose


1. Curr Alzheimer Res. 2007 Apr;4(2):117-22.
2. JAMA. 2004 Feb 11;291(6):704-10.
3. Ann Rheum Dis. 2004 Feb;63(2):200-5.
4. Biol Psychiatry. 2003 Sep 1;54(5):566-72.
5. Immunol Allergy Clin North Am. 2003 Feb;23(1):15-39.
6. Ann N Y Acad Sci. 2004 Dec;1035:104-16. Review.
7. Phys Sportsmed. 2008 Dec;36(1):11-7.
8. Prostaglandins Other Lipid Mediat. 2008 Dec;87(1-4):14-9
10. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.
11. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study.
12. Effect of methylsulfonylmethane supplementation on exercise – Induced muscle damage and total antioxidant capacity.
72. J Agric Food Chem. 1981 Sep-Oct;29(5):1089-91.
73. J Biol Chem 1940;134:781-2.
74. Arch Biochem Biophys 1966;113:251-2.
75. Toxicol Lett 2001;123:169-177.
76. Altern Med Rev. 2003 Nov;8(4):438-41.
77. Osteoarthritis Cartilage. 2008 Nov;16(11):1277-88.
78. Osteoarthritis and Cartilage 2006;14:286-94.
79. Int J Anti-Aging Med 1998;1(1):50.
80. Clin Drug Invest 2004; 24:353-63.
81. Iran J Pharmacol Ther 2004;3:61-5.
82. Federation of American Societies for Experimental Biology 69th Annual Meeting, Anaheim, California, April 21-26, 1985:Abstract 692.


* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.



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