Life Extension Circadian Sleep, Nobiletin & Melatonin, 30 Liquid Vegetarian Capsules

List Price: $32.00
Our Price: $28.00

When it comes to something as important as a healthy sleep cycle, why stop at just melatonin? Nobiletin is a flavonoid which has been extensively studied for its circadian rhythm support properties. Life Extension Circadian Sleep combines both of these powerful sleep support ingredients in one cutting-edge formulation.

  • Earn 10% Cash Back Rewards
  • Deliver on your schedule
  • Modify or Cancel any time
Purchasing this product today earns you 28 DR Reward Points!
SKU: 02300 Category:


  • Circadian Sleep features 50 mg of Nobiletin and 1.5 mg of melatonin per liquid capsule.
  • Designed to restored the body’s circadian clock.
  • Recent studies have shown that nobiletin may be under-utilized in sleep aid supplements.
  • Healthy sleep can lead to improved focus, energy, and mood throughout even the busiest of days.
  • May provide additional antioxidant and anti-inflammatory support.
  • The next step up from Life Extension’s standard melatonin supplements.
  • Vegetarian-friendly and free from GMO.

Beyond Melatonin: Nobiletin’s Astounding Potential for Circadian Support

While many are familiar with melatonin, and its role in a healthy sleep cycle (circadian rhythm), not so many are aware of the amazing sleep support potential behind nobiletin. But just what is this ingredient? What are its sources and nutritional benefits?

Nobiletin is a flavonoid which is extracted from citrus peels. The depth and breadth of its health benefits are still only beginning to be unveiled through clinical studies.

While there is a robust body of scientific literature surrounding the anti-inflammatory actions of Nobiletin, of particular interest are the studies which outline its effects on a healthy circadian rhythm in humans.

But first, what makes circadian rhythms so important? It turns out that every living thing experiences some form of 24 hour cycle which utilizes environmental changes for the sake of energy production and other physiological functions. This cycle is what is generally referred to as one’s circadian rhythm and it plays a massive role in energy and focus levels throughout the day.

According to one study on the subject, the targeting of ‘retinoid acid receptor-related orphan receptors (RORs)’ by Nobiletin reveals potential for a pharmacological intervention that enhances circadian rhythms.1 Such support for a healthy and balanced circadian rhythm provides all of the health benefits associated with a well-regulated sleep schedule.



  • If pregnant, nursing, or undergoing treatment for a medical condition, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

Supplement Facts

Serving Size: 1 Liquid Vegetarian Capsule

Servings Per Container: 30

Amount Per Serving
Nobiletin [from young citrus fruit (peel)] 50 mg
Melatonin (as MicroActive®) 1.5 mg
Other Ingredients: medium chain triglycerides, vegetable capsule (hydroxypropyl methylcellulose, chlorophyllin), microcrystalline cellulose, sodium alginate, carnuba wax, silica.

Dosage & Use

  • Take one (1) capsule daily, before bedtime, or as recommended by a healthcare practitioner.
  • Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.


There are no reviews yet.

Be the first to review “Life Extension Circadian Sleep, Nobiletin & Melatonin, 30 Liquid Vegetarian Capsules”

Your email address will not be published. Required fields are marked *


1.) The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome