Consuming alcoholic beverages results in the generation of free radicals. People who drink a lot of alcohol often suffer because of massive free radical-induced cellular damage. Alcohol-induced free radical assault can wreak short-term havoc throughout the body, and these same damaging free radicals are associated with accelerated aging.
Reactive oxygen species (ROS) have been associated with acute ethanol-induced liver damage. A study published in the journal Artery confirmed a specific toxic metabolite of alcohol (acetaldehyde) and identified an antidote (N-acetyl-L-cysteine): “All known pathways of ethanol metabolism result in the production of acetaldehyde, a highly reactive compound. N-acetyl-L-cysteine (NAC), an analogue of the dietary amino acid cysteine, binds acetaldehyde, thus preventing its damaging effect on physiological proteins.”59 NAC is a glutathione precursor and direct antioxidant. Pretreatment with or co-administration of NAC helps to inhibit acute ethanol-induced liver damage via counteracting ethanol-induced oxidative stress.60,61 NAC also attenuates the progression of the abnormal retention of lipids within liver cells by decreasing development of oxidative stress and subsequent increases in TNF-alpha.
Thus, when people are exposed to a known toxic substance such as alcohol, it makes perfect sense to take a proven antidote – namely, antioxidants.
Life Extension Anti-Alcohol with HepatoProtection Complex is an improved formula containing additional antioxidants designed to suppress free radicals, neutralize toxic alcohol metabolites such as acetaldehyde,62-65 and support healthy liver function. In addition to vitamin B1, vitamin C, N-acetyl-L-cysteine and benfotiamine, this formula’s HepatoProtection Complex provides therapeutic doses of these novel antioxi-dants:
- Chlorophyllin: an agent that protects the body from oxidative stress66-68
- Leucoselect® grapeseed extract, silymarin (from milk thistle), and trans-resveratrol: three hepatoprotective agents that aid in reducing compounds from potentially toxic xenobiotics and protecting cells from free radical-induced oxidative stress69-71
- Picroliv® Picrorhiza kurroa root extract: contains antioxidant kutkin that scavenges alcohol-induced excess free radi-cals and stimulates regeneration of cells (hepatocytes)72,73
Taking the proper supplements before and after drinking can substantially protect liver cells from the free-radical damaging effects of alcohol consumption.
Serving Size: 5 vegetarian capsules
Servings Per Container: 12
Amount Per Serving
Vitamin C (as ascorbic acid)
Vitamin E (as D-alpha tocopheryl succinate)
Thiamine (vitamin B1) (as thiamine HCl)
Zinc (as zinc oxide)
Selenium (as sodium selenite)
Clovinol® clove extract (flower bud) [std. to 30% polyphenols]
Chlorophyllin (from sodium magnesium chlorophyllin)
Leucoselect® grape seed extract (seed) [std. to 95% proanthocyanidins]
Silymarin [from milk thistle extract (seed)]
Barley grass whole powder (leaf)
Trans-Resveratrol [from Japanese knotweed (root) and and red grape (fruit) extracts]
Other Ingredients: vegetable cellulose (capsule), l-leucine, silica, microcrystalline cellulose.
Clovinol® is a registered trademark of Akay USA LLC.
Leucoselect® is a registered trademark of Indena USA, U.S. Reg No. 2294439.
Dosage and Use:
- Adults age 21 and over, take one (1) capsule with each alcoholic beverage, up to five capsules per day, or as recommended by a healthcare practitioner.
- Five capsules may also be taken at once before or after consuming alcoholic beverages.
Caution: This product does not prevent or reduce the mental impairment effects alcohol induces. Do not drink and attempt to drive or operate equipment or heavy machinery. Consult your healthcare provider before use if you are taking medication.
- If pregnant, nursing, or taking medication, consult your physician before taking this product
- Keep out of reach of children
- Do not exceed recommended dose
59. Artery. 1995; 21(6):312-6.
60. Hepatol Res. 2006 Mar;34(3):199-206;
61. World J Gastroenterol. 2003 Apr;9(4):791-4.
62. Biochem Pharmacol. 1994 Aug 3;48(3):621-4.
63. Alcohol. 1999 Feb; 17(2):163-8.
64. Fiziol Zh. 1996; 42(1-2):65-72.
65. Neuroreport. 1999 Jan 3;10(8):1799-801.
66. Biochim Biophys Acta. 2000 Sep 27;1487(2-3):113-27.
67. Biochim Biophys Acta. 2004 May 3;1672(2):100-11.
68. Z Naturforsch [C]. 2007 Mar-Apr;62(3-4):215-22.
69. Turk J Gastroenterol. 2008 Jun;19(2):92-8.
70. Chem Biol Interact. 2008 Dec 24. [Epub ahead of print]
71. World J Gastroenterol. 2008 Dec 14;14(46):7101-6.
72. Curr Pharm Biotechnol. 2009 Sep;10(6):641-9.
73. Indian J Exp Biol. 2010 Mar;48(3):323-8.
* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.