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Life Extension Acetyl-L-Carnitine, 500 mg, 100 Vegetarian Capsules

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Acetyl-L-carnitine assists in maintaining cellular energy metabolism by facilitating the transport of fatty acids from the cytosol into the mitochondria. Fats are oxidized to produce energy. This is the acetylated ester of the amino acid L-carnitine.

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Description

A major cause of aging is a reduction in the energy-producing components of the cell, resulting in reduced cellular metabolic activity, and the accumulation of cellular debris.1-7 L-carnitine helps maintain cellular energy metabolism by assisting in the transport of fatty acids from the cytosol into the mitochondria within the cell, where fats are oxidized to produce the cellular energy (adenosine triphosphate or ATP).8-13

Acetyl-L-carnitine is the acetylated ester of the amino acid L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane compound that helps maintain mitochondrial bioenergetics and lowers the increased oxidative stress associated with aging.14 Acetyl-L-carnitine and L-carnitine are absorbed into the bloodstream efficiently. Both are effective at carrying long-chain fatty acids across the membrane into the mitochondria where they are burned for energy production and utilized efficiently by the cells.15-18 Acetyl-L-carnitine also guards against oxidative damage.5,19-21 Amyloid-beta peptide is a principal component of plaques and is thought to be a contributor to the aging process. Acetyl-L-carnitine exerts protective effects against such neurotoxicity and oxidative stress.14

Acetyl-L-carnitine (ALC) easily crosses the blood-brain barrier and may have potential in exerting unique neuroprotective, neuromodulatory and neurotrophic properties. ALC may support youthful memory function, improve mitochondrial structure and function, prevent age-related oxidative damage, and restore the activity of key enzymes.22-28

 

Supplement Facts

Serving Size: 2 capsules

Servings Per Container: 50

Amount Per Serving

Acetyl-L-Carnitine (from acetyl-L-carnitine hydrochloride)

1000 mg

Other Ingredients: vegetable cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, silica, medium chain triglycerides.

Dosage and Use:

  • Take two capsules once or twice daily, or as recommended by a healthcare practitioner.
  • This product is best utilized when taken on an empty stomach with water or juice in divided doses 45 minutes before breakfast and lunch.

Caution: For some people, L-carnitine, especially acetyl-Lcarnitine, may have a stimulating effect. Therefore, it may be unwise to take it in the evening.

Warnings:

  • If pregnant, nursing, or taking medication, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose

References:

1. Physiol Rev.1998 Apr;78(2):547-81.
2. Ann N Y Acad Sci. 2004 Jun;1019:406-11.
3. Age. 1983 6:86-94.
4. Exp Gerontol. 1984;19(1):31-6.
5. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10771-8.
6. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3064-9.
7. Ann N Y Acad Sci. 1998 Nov 20;854:118-27.
8. Brain Res. 1990 Aug 27;526(1):108-12.
9. Metabolism. 1997 Dec;46(12):1454-7.
10 Mech Ageing Dev. 1995 Oct 13;84(2):103-12.
11. Ann N Y Acad Sci. 2002 Apr;959:491-507.
12. Physiol Rev. 1983 Oct;63(4):1420-80.
13. Am J Clin Nutr. 2007 Dec;86(6):1738-44.
14. J Neurosci Res. 2006 Aug 1;84(2):398-408.
15. Acta Diabetol. 2003 Oct;40 Suppl 1:S106-13.
16. Biochim Biophys Acta. 2000 Jun 26;1486(1):1-17.
17. J Clin Invest. 1989 Oct;84(4):1167-73.
18. Exp Physiol. 2008 Oct;93(10):1139-46.
19. Neurochem Res. 2009 Apr;34(4):755-63.
20. Ann N Y Acad Sci. 2004 Nov;1033:117-31.
21. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1876-81.Erratum in: Proc Natl Acad Sci U S A 2002 May 14;99(10):7184.
22. Neurochem Res. 2003 Sep;28(9):1321-8.
23. Ann N Y Acad Sci. 2004 Nov;1033:108-16.
24. Geriatr Gerontol Int. 2010 Jul;10 Suppl 1:S99-106.
25. Neuropharmacology. 2008 Aug;55(2):223-9.
26. Arch Gerontol Geriatr. 2008 Mar-Apr;46(2):181-90.
27. Eur J Pharmacol. 2007 Sep 10;570(1-3):97-107.
28. Brain Res. 2005 Nov 9;1061(2):114-7.
29. Effect of oral acetyl L-carnitine arginate on resting and postprandial blood biomarkers in pre-diabetics
30. Office of Dietary Supplements: Carnitine

 

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

 

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