Acetyl-Glutathione is a novel oral Glutathione formulation that is stable in the stomach and gastrointestinal tract, well absorbed, and able to enter the cells directly and present to the Cytosol for mitochondrial entry. Unlike other forms of Glutathione, Acetyl-Glutathione tablets are odor-free and easy to take. Glutathione is found throughout the body, and is concentrated in the liver and kidneys, as well as the lining of the lungs and intestines. It is thought to be the body’s major endogenous antioxidant, playing a central role in maintaining the redox state of every cell in the body. Besides directly reacting with oxidants, it may also help recycle other antioxidants back to their reduced forms, both endogenous antioxidants such as Glutaredoxins, and exogenous antioxidants including Vitamins C and E. It may also serve as a co-factor for Glutathione Peroxidases, and is thought to be involved in the regulation of the Nitric Oxide cycle. Glutathione supports the liver and kidney detoxification processes, and Glutathione levels are considered by many a key marker of immune status.”
Because Glutathione is a tripeptide (i.e., made of three amino acids), oral reduced Glutathione has unfavorable biochemical and pharmacokinetic properties. It is not well absorbed from the gut, it has a short half-life in blood plasma, and it is not clear that it is transported into cells to any significant extent. When taken orally, the body must break most of the Glutathione into its component amino acids (cysteine, Glutamate, Glycine) to allow absorption into the blood stream. Even if some whole Glutathione does gain access to the blood stream, in order to be taken up by cells, it must be broken down and re-synthesized to Glutathione intracellularly. Metabolic and enzymatic obstacles in the body can and do impair these processes.
S-Acetyl-Glutathione is one of several reversible bioconjugates of Glutathione that are stable in plasma, and that can be taken up by cells directly. De-acetylation is an ordinary occurrence in cells, and once in the cells, S-Acetyl-Glutathione is naturally de-acetylated to Glutathione. S-Acetyl-Glutathione contains one Acetyl group on the Sulfhydryl portion of the peptide. Intracellularly, the Acetyl group is removed to replenish Glutathione for mitochondrial action.
Glutathione’s many important properties are considered to be:
- Heavy metal toxicity including mercury, lead, arsenic and cadmium
- Common toxins that glutathione may help protect against are car exhaust, cigarette smoke, aspirin and alcohol (Marz, p. 78, 1997)
- Pesticide and industrial chemical exposure
- Bacterial toxins (Clostridia difficile)
- Pharmaceuticals (very long list that need to be detoxified by the liver) (Marz, p. 79, 1997)
- Immune enhancement: 1-3 g per day. This is especially effective against clostridium in the GI. It helps prevent translocation.
- Diabetes mellitus: Especially in ketosis as DM patients will generally excrete increased amounts of sulfur containing amino acids.
- Liver disease including cirrhosis and fatty liver disease caused by alcohol: Clinical Research and Case studies show significant improvement in as little as 2 weeks.
- Ulcers intestinal or stomach: In patients with stomach ulcers low levels of GSH have been found.
- Aspirin or phenacetin overdose (useful for rheumatoid arthritis patients or chronic pain sufferers on 8 or more aspirin/day)
- Hematological conditions: myelofibrosis, acute leukemia, chronic myelocytic leukemia, lymphoma, polycythemia vera
- Before radiation therapy
- Detached Retinas
- Parkinson’s disease, Alzheimer’s Disease, ALS (Lou Gherig’s disease), Multiple Sclerosis,, other neurologic conditions including Autism/Pervasive Developmental Delay and Chronic Kidney Failure
Therapeutically, Glutathione may be:
- Found in almost all living cells. The liver, spleen, kidneys, pancreas, and the lens and cornea, have the highest concentrations in the body
- A POWERFUL ANTIOXIDANT and thus neutralizes free radicals and prevents their formation
- An Important role in immune function via white blood cell production and is one of the most potent anti-viral agents known
- One of the strongest anti-cancer agents manufactured by the body
- Used by the liver to detoxify toxins including formaldehyde, acetaminophen, benzpyrene and many other compounds
- An antioxidant necessary for the protection of proteins; is involved in nucleic acid synthesis and plays a role in DNA repair
- Powerful enough to maintain the cellular redox potential
- Glutathione levels decrease with age. It is involved in cellular differentiation and slows the aging process
- Able to protect the integrity of red blood cells
- Involved in maintaining normal brain function
Serving Size: 1 tablet
Servings Per Container: 60
Amount Per Serving
Other Ingredients: Microcrystalline Cellulose, proprietary fruit acid, rice-starch, silica, vegetable magnesium stearate
***Patent Pending (#MJ923)
Dosage and Use:
- 1 tablet two times daily, or as directed by a healthcare professional
- If pregnant or lactating, consult your physician before taking this product
- Keep out of reach of children
- Do not exceed recommended dose
* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.