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Zetpil Seratone Stress Suppositories, 30 Count

Item Number: SER01 | 1 Reviews

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List Price: $120.00
Our Price: $99.00
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Supplement Overview

Item Catalog Number: SER01
30 Suppositories
Click for Research Links
Click to View Supplement Facts
All Suppositories and Creams

Benefits of Seratone Suppositories

  • Purest pharmaceutical grade L-5-HTP with the highest concentrations available.
  • Encourages brain serotonin levels and positive effects on emotional well-being.
  • May support weight loss and appetite control.
  • May aid in the treatment of depression, anxiety and insomnia.
  • No degradation through digestion as with oral supplements.
  • Provides maximum absorption into the bloodstream via suppository form, up to an 85% absorption rate.
  • Suppository supplements may effectively achieve therapeutic dosages.
  • Made of a proprietary base to allow proper absorption through the intestinal wall.

Seratone suppositories are designed using a proprietary blend of the purest pharmaceutical grade L-5-HTP. L-5-HTP (5-Hydroxytryptophan) is derived from the herb Griffonia Simplicifolia using Griffonia seeds which contain the highest concentration of L-5-HTP available.

Recent research suggests that the concentrate from these seeds raises serotonin levels which is imperative in regulating brain chemistry and aids in the treatment of depression, anxiety and insomnia.

L-5-HTP is also believed to aid in the regulation of appetite and to work as an effective pain reducer. Unlike oral 5HTP, the suppository form has clinically demonstrated that it delivers a therapeutic dosage that is capable of penetrating the blood brain barrier without the side effects nausea, diarrhea and vomiting that are attributed to much lower and significantly less effective oral dosages of 5HTP.

Are the Suppositories Heat Sensitive?

The suppositories do not need to be refrigerated as heat will not affect their quality or potency. The suppository base is a superior form that uses an inclusion formula with heat stable ingredients. Nonetheless, we do give the option of purchasing ice, as some customers prefer it that way. Refrigeration is for "hardening" the suppository to facilitate insertion.

Supplement Facts

Serving Size: 1-2 suppositories per day
Servings Per Container: 30

Amount Per Serving

B1 (proprietary blend of bioactive absorbable forms of thiamine)

8 mg

B2 (proprietary blend of bioactive absorbable forms of riboflavin)

6 mg


11 mg

B6 (proprietary blend of bioactive forms of Pyridoxine)

6 mg

B5 (DiCalcium Pantothenic Acid)

11 mg

UltraPure Biotin

0.6 mg


400 mcg


0.5 mg

Folinic Acid

1 mg


150 mg

Mixed Tocopherols


Proprietary Blend: 480mgs of 5-HTP (5-Hydroxytryptophan) Griffonia Seed Extract 98%, L- Theanine 98% and L-Citrulline.


Suppository Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives.

Other Ingredients: This product contains an extract from soybeans.

Dosage and Use:

  • 1 to 2 suppositories per day.
  • This product can be taken at any time during the day.
  • This product may also be used as a sleep aide.
  • Since serotonin is produced in the brain in the waking state, this product should be taken in the evening, at least 1 hour before bedtime.
  • It is recommended that you always attempt to move your bowels prior to inserting the suppository(s) to avoid discharging of the suppository before the suppository can be totally absorbed.
  • It is recommended that the suppository be retained for approximately 15-20 minutes to ensure adequate absorption of the nutraceutical, herbal and nutrient ingredients contained herein.
  • To facilitate insertion it is recommended you moisten suppository with warm water.
  • If inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion.

Research Links:

Caution: Storing this product at room temperature will not alter the effectiveness or potency. However a firm suppository is necessary for a comfortable and easy insertion. Therefore we recommend that this product be stored in the refrigerator to maintain firmness. If the suppository does become soft, place the suppository in the refrigerator to achieve the firmness needed for comfortable insertion Avoid excessive heat 40°C (104°F). Store in a cool place 8° to 15°C (46° to 59°F) or refrigerate. When using nutritional supplements or nutraceuticals, please inform your physician if you are undergoing treatment for a medical condition healthcare professional. Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository or as a vaginal pessary. However, this product can also be taken safely by mouth. If one chooses to take this product orally, this this product may be considered a dietary supplement in accordance with current FDA guidelines.

  • Although extremely rare, 5HTP (5-Hydroxytryptophan) delivered via rectal suppository may cause some transient nausea, diarrhea or vomiting more often associated with oral ingestion of 5HTP(5-Hydroxytryptophan). If this occurs reduce dosage in half for approximately 1 week before resuming normal dose.
  • If you are taking Monoamine Oxidase Inhibitors, trycyclic antidepressants, serotonin re-uptake inhibitors (SSRIs) or other psychotropic medications, or if you have heart disease please consult your physician, or your healthcare provider.
  • Not recommended for anyone with hemophilia or clinically elevated blood pressure without consulting your physician or healthcare provider.


  • If pregnant or lactating, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose
  • Do not use if the suppositories are open or damaged.
  • Patients who are allergic or sensitive to phospholipids should avoid taking this product.
  • If you experience any adverse effect, discontinue and contact your healthcare provider before resuming use.


1. Griffonia simplicifolia Baill
2. 5-HTP

How To Insert Rectal Suppositories

  1. Wash your hands thoroughly with soap and water. Prior to using/inserting suppositories, it is best to attempt to evacuate by attempting to have a bowel movement. We recommend, if possible, that the suppositories be inserted after you have attempted to move your bowels. This helps in the first of the four pharmacokinetic processes: absorption, distribution, metabolism, elimination (Hollenberg & Brody, 1998). If you chose to use a latex glove to insert the suppository, place the glove on the hand you will use to insert the suppository. Gloves are very inexpensive and can be purchased at most pharmacies.
  2. Take the suppository out of the refrigerator. The suppositories retain cold so they will be comfortable. By keeping the suppository in the refrigerator, the suppository will be hard and easier to insert. ONLY the DMSA suppository cannot be refrigerated or kept in freezer since the cold decreases potency.
  3. Open plastic suppository shell by pulling apart the 2 tabs located at the tapered end.
  4. If necessary, lubricate the suppository tip with tap water or a water-soluble lubricant such as K-Y Lubricating Jelly, NOT PETROLEUM JELLY (VASELINE). If you do not have this lubricant, moisten the SUPPOSITORY with cool tap water. Note that after a shower, insertion is quite easy. Note that the use of the lubricating jelly and/or cool water will hasten the separation of the base material form the nutrients, and thus enhance the absorption process.
  5. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach.
  6. Lift upper buttock to expose the rectal area.
  7. Insert the suppository flat side first (not the tapered end pushing with your finger until it passes the muscular sphincter of the rectum, about 1/2 to 1 inch in infants and 1 inch in adults.) By inserting the flat end first retention and post insertion comfort is improved. If the suppository is not inserted past this sphincter muscle, the suppository may pop out. The placing of the flat side first into the rectum triggers a reflex contraction of the rectal tissue that causes the suppository to be pulled up into the rectum where it is more comfortably retained.
  8. Hold buttocks together for a few seconds and you are finished!
  9. Discard used materials and wash your hands thoroughly. If you have used a latex glove, pull the glove inside out then discard. Remember, if you have problem with retaining the suppository, a simple strategy to insure retention is to lying down for about 5-15 minutes as this will help you retain the suppository.

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

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Customer Reviews

Kathleen | 03/04/2013 |

ZETPIL Seratone and Multi Vitamin with Iron have saved my life. I have been on them for 8 years. I\'m sure you know that Zetpil is a genius. When I went through menopause I completely stopped sleeping for many years (maybe slept an hour a night) I tried everything herbal and pharmaceutical and nothing worked until I discovered the Seratone. It didn\'t happen overnight but over a period of months they changed my life. At the same time I had a horrible case of Restless Leg Syndrome where my entire body would twitch and spasm all night long (The insomnia started and then the RLS). Nothing worked for that either until I discovered that iron could help. I took oral iron for almost a year before discovering Zetpil with no results. Then I started on the zetpil multi with iron (it had a different name then) and finally my ferritin went up to the point that my body was quiet enough to live. I credit both of these products for my present quality of life which is pretty darn good.

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