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Zetpil Seratone Stress Suppositories, 30 Count

Item Number: SER01 | 1 Reviews

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List Price: $120.00
Our Price: $99.00
Your Savings: $21.00

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Supplement Overview

Item Catalog Number: SER01
30 Suppositories
Click for Research Links
Click to View Supplement Facts
How to Insert a Suppository
All Suppositories and Creams

Serotonin is an important neurotransmitter which plays many roles throughout the body. Deficiencies in serotonin are often associated with a number of health concerns stemming from the brain and central nervous system. These suppositories contain 5-HTP, a precursor to the formation of serotonin which is capable of passing through the blood-brain barrier.

  • Contains 480 mg of serotonin precursor 5-HTP
  • 5-HTP is able to pass through the blood-brain barrier and support serotonin production in the brain
  • Also includes numerous B complex vitamins often used for nutritional brain health support
  • Suppository base provides much higher absorption rates than oral supplements

Serotonin and a Healthy Brain

Serotonin is a chemical and neurotransmitter found in high concentrations in the brain, bowels, and bloodstream. As a neurotransmitter, serotonin is thought to play a role in everything from muscle contraction to mood and stress regulation.

Because so much of the body’s supply of serotonin is made and contained in the brain, it is not entirely surprising that serotonin plays a pivotal role in multiple aspects of brain functionality. In fact, serotonin deficiencies are thought of as a possible contributor to multiple health concerns rooted in the brain and central nervous system such as high stress levels and difficulties with sleeping.1

Raising Serotonin Levels in the Brain

One difficulty with raising serotonin levels is that serotonin itself is incapable of passing through the blood brain-barrier (BBB). The BBB is a protective membrane which regulates what can or cannot pass from the blood into the brain. This means that any ingested serotonin is useless to the brain, even if it is able to reach the bloodstream in significant quantities.

These suppositories utilize 5-Hydroxytryptophan (5-HTP), a chemical which is a precursor to the formation of serotonin.2 The most pivotal feature of 5-HTP is that it is capable of passing through the BBB.3 The 5-HTP in these suppositories is released directly to the blood through the porous tissues of the lower bowels. From there, it is able to be used for the production of serotonin in the brain. By assisting serotonin production, 5-HTP could play a supportive role in counteracting an identified serotonin deficiency in the brain.

Are the Suppositories Heat Sensitive?

The suppositories do not need to be refrigerated as heat will not affect their quality or potency. The suppository base is a superior form that uses an inclusion formula with heat stable ingredients. Nonetheless, we do give the option of purchasing ice, as some customers prefer it that way. Refrigeration is for "hardening" the suppository to facilitate insertion.

Supplement Facts

Serving Size: 1-2 suppositories per day
Servings Per Container: 30

Amount Per Serving

B1 (proprietary blend of bioactive absorbable forms of thiamine)

8 mg

B2 (proprietary blend of bioactive absorbable forms of riboflavin)

6 mg


11 mg

B6 (proprietary blend of bioactive forms of Pyridoxine)

6 mg

B5 (DiCalcium Pantothenic Acid)

11 mg

UltraPure Biotin

0.6 mg


400 mcg


0.5 mg

Folinic Acid

1 mg


150 mg

Mixed Tocopherols


Proprietary Blend: 480mgs of 5-HTP (5-Hydroxytryptophan) Griffonia Seed Extract 98%, L- Theanine 98% and L-Citrulline.


Suppository Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives.

Other Ingredients: This product contains an extract from soybeans.

Dosage and Use:

  • 1 to 2 suppositories per day.
  • This product can be taken at any time during the day.
  • This product may also be used as a sleep aide.
  • Since serotonin is produced in the brain in the waking state, this product should be taken in the evening, at least 1 hour before bedtime.
  • It is recommended that you always attempt to move your bowels prior to inserting the suppository(s) to avoid discharging of the suppository before the suppository can be totally absorbed.
  • It is recommended that the suppository be retained for approximately 15-20 minutes to ensure adequate absorption of the nutraceutical, herbal and nutrient ingredients contained herein.
  • To facilitate insertion it is recommended you moisten suppository with warm water.
  • If inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion.

Research Links:


1. Serotonin Information
2. 5-HTP Information
3. 5-HTP Blood-Brain Barrier

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

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Customer Reviews

Kathleen | 03/04/2013 |

ZETPIL Seratone and Multi Vitamin with Iron have saved my life. I have been on them for 8 years. I\'m sure you know that Zetpil is a genius. When I went through menopause I completely stopped sleeping for many years (maybe slept an hour a night) I tried everything herbal and pharmaceutical and nothing worked until I discovered the Seratone. It didn\'t happen overnight but over a period of months they changed my life. At the same time I had a horrible case of Restless Leg Syndrome where my entire body would twitch and spasm all night long (The insomnia started and then the RLS). Nothing worked for that either until I discovered that iron could help. I took oral iron for almost a year before discovering Zetpil with no results. Then I started on the zetpil multi with iron (it had a different name then) and finally my ferritin went up to the point that my body was quiet enough to live. I credit both of these products for my present quality of life which is pretty darn good.

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