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Zetpil Arginine Plus Suppositories, 60 Count

Item Number: ARG01 | 1 Reviews

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List Price: $130.00
Our Price: $109.00
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Supplement Overview

Item Catalog Number: ARG01
60 Suppositories
Also available: 6.5 Fluid oz Cream
Click for Research Links
Click to View Supplement Facts
How to Insert a Suppository
All Suppositories and Creams

Arginine is perhaps the most important amino acid for heart health. It is a highly effective supplement that can be used to support healthy blood pressure levels* and the production of nitric oxide. As much as 85% of arginine taken orally experiences significant enzymatic degradation, so taking arginine in the form of a suppository is necessary to ensure its overall effectiveness.

  • Helps to support blood vessels, natural nitric oxide production levels, healthy blood pressure*, and other areas of heart health
  • Bypass degradation in the stomach or liver experienced by oral Arginine supplements
  • Provides maximum absorption into the bloodstream via suppository form, second only to an IV
  • Suppository supplements can effectively achieve proper dosages
  • Made of a proprietary base to allow proper absorption through the intestinal wall

Oral Ingestion of Arginine and its Potential Harms

Even though oral arginine can be completely ineffective in small doses, if the dosages are too high (depending on the individual recipient) arginine can actually disrupt endothelial nitric oxide synthase (eNOS) levels by activating a feedback mechanism which the body utilizes to mitigate excessive formation of nitric oxide (NO). Said mechanism only exists because of the immense bodily damage that excessive NO levels can cause. In the body, excessive NO facilitates the creation of the most damaging free radical, a prooxidant known as peroxynitrite.

Previously performed research has demonstrated that recipients of oral arginine need as much as 11 grams. Unfortunately, this amount is not sustainable from a patient compliance perspective in order to reach the pharmacodynamically effective level which is needed by the majority of the patient population to substantially raise their endothelial NO. Such a high oral dosage is necessary due to the fact that arginine experiences approximately an 85% enzymatic degradation when ingested orally.

Why a Suppository?

The difference in effectiveness between an arginine suppository supplement and an oral arginine supplement is so profound that there is simply no point in comparing the two in terms of quality. Suppositories provide a more effective rate of absorption without degradation from the digestive tract. Additionally, repeated ingestion of oral arginine may eventually lead to the body's inability to utilize the supplement, creating an extended deficiency in Arginine!

Are the Suppositories Heat Sensitive?

The suppositories do not need to be refrigerated as heat will not affect their quality or potency. The suppository base is a superior form that uses an inclusion formula with heat stable ingredients. Refrigeration is for "hardening" the suppository to facilitate insertion. Nonetheless, we do give the option of purchasing ice, as some customers prefer it that way.

Supplement Facts

Serving Size: 2 Suppositories
Servings Per Container: 30

Amount Per Serving

L-Arginine [a proprietary blend of three of the most active forms of the free amino]

444 mg


160 mg


5 mg


5 mg

Folinic Acid

1.3 mg

Suppository Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives.

Other Ingredients: This product contains an extract from soybeans. This product contains NO milk, egg, fish, peanuts, crustacean (lobster, crab, & shrimp), tree nuts, wheat, yeast, gluten corn, rice, sugar, preservatives or hydrogenated oils.

Dosage and Use:

  • 2 suppositories per day
  • This product can be taken at any time during the day, but we recommend it is best taken before retiring at night to facilitate maximum absorption and retention.
  • It is recommended that you always attempt to move your bowels prior to inserting the suppositories to avoid discharging of the suppository before the suppository can be totally absorbed.
  • To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water.
  • It is recommended that the suppository be retained for approximately 10-15 minutes to ensure complete absorption of the ingredients.
  • Although not required, if inserted while lying on one's side, consider remaining in the supine position for 1-3 minutes following insertion.

Research Links:

* Blood pressure levels already within a natural range

** These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

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Customer Reviews

Kreshton | 03/03/2013 |

Thank you for processing my order! It\'s been a privilege getting to work with you and I am totally satisfied with the results. Please count me in as your number 1 favorite customer!

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