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Life Extension TMG (trimethylglycine) Powder, 50 grams

Item Number: 00349 | Be the first to review this product!

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List Price: $14.00
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Supplement Overview

Item Catalog Number: 00349
50 grams (1.76 oz) Powder
Click to View Supplement Facts

Methylation has been shown to reduce homocysteine levels and raise methionine levels. TMG is a cofactor in this process. Trimethylglycene helps synthesize serotonin and melatonin, raises SAMe levels and supports nonalcoholic fatty liver disease.

Trimethylglycine (TMG) is also called glycine betaine, but the name trimethylglycine signifies that it has three methyl groups attached to each molecule of glycine. TMG was discovered to be beneficial to heart health back in the 1950s.105-109 TMG operates along a pathway similar to that of vitamin B12: It is a "methyl donor," providing extra methyl groups to hasten the conversion of homocysteine back to methionine.110 When a TMG methyl group is donated to a molecule of homocysteine, it converts to the non-toxic amino acid, methionine.111,112 Research showing TMG’s ability to promote healthy levels of homocysteine, alone or in conjunction with other nutrients, confirms its status as an important nutrient for cardiovascular health.113-121 For example, in a recent cross-sectional survey study, participants who consumed > 360 mg/d of TMG had, on average, 10% lower concentrations of homocysteine and 19% lower concentrations of C-reactive protein than those who consumed < 260 mg/d.122

Symptoms of increased levels of homocysteine include:3

  • Extreme tiredness
  • Osteoporosis
  • Blood clots
  • Seizures
  • Abnormal bone structure

Studies suggest that TMG may benefit those with Nonalcoholic Fatty Liver Disease. One human study done at the Mayo Clinic reported improvement in steatosis, inflammation and fibrosis.2

Supplement Facts

Serving Size: 1 rounded scoop (515 mg)

Servings Per Container: about 97

Amount Per Serving

Trimethylglycine (TMG) (as betaine anhydrous)

500 mg

Other Ingredients: none.

Dosage and Use:

  • Take two tablets in the morning with or without food, or as recommended by a healthcare practitioner.
  • TMG should be taken with co-factors vitamins B6, B12, and folic acid.

Caution: If muscle tension or headaches occur, reduce dose or discontinue product, and inform your physician if they do not subside.


  • If pregnant, nursing, or taking medication, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose


1. Wikipedia: Trimethylglycine
2. Treatment Options for Nonalcoholic Fatty Liver Disease
3. MedlinePlus: Betaine
105. Ann West Med Surg. 1951;5:825-9.
106. Ann West Med Surg. 1951;5:830-55.
107. Ann West Med Surg. 1951;5:856-62.
108. JAMA. 1951;145:1232-6.
109. Am J Dig Dis. 1952;19:381-4.
110. Mol Genet Metab. 2006 Jul;88(3):201-7.
111. Biochemistry. 1999 Oct 19;38(42):13991-8.
112. Greene, R. C. 1996. Biosynthesis of methionine, p. 542-560. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed. ASM Press, Washington, DC.
113. J Nutr. 2003 Dec;133(12):4135-8.
114. J Nutr. 2003 May;133(5):1291-5.
115. Am J Clin Nutr. 2002 Nov;76(5):961-7.
116.. Br J Clin Pharmacol. 2002 Aug;54(2):140-6.
117. Kidney Int. 2002 Mar;61(3):1040-6.
118. An Esp Pediatr. 1993 Jul;39(1):37-41.
119. Metabolism. 1985 Dec;34(12):1115-21.
120. N Engl J Med. 1983 Aug 25;309(8):448-53.
121. J Nutr. 2006 Jan;136(1):34-8.
122. Am J Clin Nutr. 2008;87:424–30.

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

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