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Life Extension Resveratrol with Pterostilbene, 100 mg, 60 Vegetarian Capsules

Item Number: 01410 | Be the first to review this product!

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Supplement Overview

Item Catalog Number: 01410
60 Vegetarian Capsules
Also available: 20 mg Capsules
Click to View Supplement Facts

Life Extension Resveratrol with Pterostilbene utilizes trans-resveratrol and trans-pterostilbene along with quercetin which have anti-inflammatory, antioxidant, and antineoplastic properties. May support weight management, blood pressure, cholesterol & memory.

In 2003, the Life Extension Foundation® introduced a purified resveratrol supplement that was later documented to favorably alter some of the changes in gene expression that cause us to age. On January 25, 2009, CBS News 60 Minutes featured an in-depth report on the multiple benefits that resveratrol may confer in slowing and even reversing certain aspects of aging.

Resveratrol is a phytoalexin, a natural plant antibiotic which is produced by Vitis vinifera as a response to attack by molds. Because of the widespread use of pesticides in modern wine making, including the practice of copper sulfation, the level of resveratrol in modern wines has plummeted. Red wine contains resveratrol, but the quantity varies depending on where the grapes are grown, the time of harvest and other factors. In fact, usually only one to three mg of resveratrol per liter of red wine is currently found, even in the most robust red wines. After years of relentless research, a standardized resveratrol extract is now available as a dietary supplement.

In general, there are approximately one to three mg of resveratrol per liter currently found in red wines, even though there are exceptions.58-62 Therefore, using an average of 1.5 mg of resveratrol in 1 liter of today’s red wine, our 20 mg trans-resveratrol supplement contains approximately 476 times the amount of resveratrol in one fluid ounce of red wine. Since a glass of wine is approximately 5⅓ ounces, this means you may achieve the amount of resveratrol in 90 glasses of red wine just by taking one 20 mg trans-resveratrol supplement.

Life Extension has evaluated published studies on resveratrol to establish the doses humans might need to take to duplicate the remarkable laboratory findings. The results of Life Extension’s analysis yield a wide range of potentially effective doses: from 20 to 250 mg a day and higher. The resveratrol potency you choose may be based on your current state of health and/or your desire to reach the upper limits of a healthy human life span.

This formulation also contains trans-pterostilbene (a plant extract in the same stilbene family as resveratrol), that works synergistically with resveratrol to confer anti-aging benefits. The University of Mississippi completed a human clinical trial in April, 2012 on the effect of pterostilbene on cholesterol and blood pressure. The study showed pterostilbene was associated with lower blood pressure and weight management.19

Many experts agree the combination of ingredients in Life Extension Resveratrol with Pterostilbene may support heart health,2-6 cognitive function,7,8 anti-aging,9,10 weight management and other metabolic disorders.


Supplement Facts

Serving Size: 1 vegetarian capsule

Servings Per Container: 60

Amount Per Serving

Trans-resveratrol [from Polygonum cuspidatum (root) and whole red grape (Vitis vinifera) extract] [also supplying glycosides (polydatin)]

100 mg

Quercetin (as quercetin dihydrate)

120 mg

Trans-Pterostilbene (from pTeroPure®)

0.25 mg

Other Ingredients: vegetable cellulose (capsule), microcrystalline cellulose, silica, vegetable stearate.

Contains NO: milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, rice or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.

pTeroPure® is a registered trademark of ChromaDex, Inc.


Dosage and Use:

  • Take one capsule daily with or without food, or as recommended by a healthcare practitioner.


Caution: If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.


Warnings:

  • If pregnant, nursing, or taking medication, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose


References:

1. Riche DM, Deschamp D, Griswold ME, McEwen CL Riche KD, Sherman JJ, Wofford MR. Impact of pterostilbene on metabolic parameters in humans. Poster presentation at: American Heart Association 2012 Scientific Sessions on High Blood Pressure Research.
2. Rimando AM, Nagmani R, Feller DR, and Yokoyama W. Pterostilbene, a new agonist for the peroxisome proliferator activated receptor alpha-isoform, lowers plasma lipoproteins and cholesterol in hypercholesterolemic hamsters. J. Agric. Food Chem. 53, 3403 (2005).
3. Pan Z, Agarwal AK, Xu T, Feng Q, Baerson SR, Duke SO, Rimando AM. Identification of molecular pathways affected by pterostilbene, a natural dimethylether analog of resveratrol. BMC Med. Genomics. 1, 7 (2008).
4. Pons L. Agricultural Research/November-December 2006. This work is part of Plant Biological and Molecular Processes(#302) and Quality and Utilization of Agricultural Products (#306), two ARS National Programs described on the World Wide Web at TextofLink.
5. Mizuno CS, Ma G, Khan S, Patny A, Avery MA, Rimando AM. Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha. Bioorg. Med. Chem. 16(7), 3800 (2008).
6. Park ES, Lim Y, Hong JT, Yoo HS, Lee CK, Pyo MY, Yun YP. Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway. Vascul Pharmacol. 53, 61 (2010).
7. Joseph JA, Fisher DR, Cheng V, Rimando AM, and Shukitt-Hale B. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. J. Agric. Food Chem. 56, 10544 (2008).
8. Shukitt-Hale B, Lau FC, Joseph JA. Berry Fruit Supplementation and the Aging Brain. J. Agric. Food Chem. 56, 636 (2008).
9. Joseph JA, Fisher DR, Cheng V, Rimando AM, and Shukitt-Hale B. Cellular and behavioral effects of stilbene resveratrol analogues: implications for reducing the deleterious effects of aging. J. Agric. Food Chem. 56, 10544 (2008).
10. Shukitt-Hale B, Lau FC, Joseph JA. Berry Fruit Supplementation and the Aging Brain. J. Agric. Food Chem. 56, 636 (2008).
11. USDA: Pterostilbene’s Healthy Potential
12. PubMed: Pterostilbene and cancer: current review..
13. USDA: Antioxidant Effect of trans-Resveratrol, Pterostilbene, Quercetin and Their Combinations in Human Erythrocytes In Vitro
14. National Institute on Aging: Topics of Interest: Resveratrol
19. Daniel M. Riche , PharmD, Cardiometabolic Clinic Coordinator at the University of Mississippi School of Pharmacy. 58. Nahrung. 2000 Aug;44(4):253-6.
59. J Agric Food Chem. 2004 Aug 25;52(17):5396-403.
60. J Agric Food Chem. 2009 Aug 12;57(15):6770-8.
61. J Agric Food Chem. 2007 Aug 8;55(16):6807-12.
62. J Chromatogr Sci. 2010 Mar;48(3):229-34.


* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.


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