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Life Extension Enhanced Natural Sleep without Melatonin, 30 Capsules

Item Number: 01511 | Be the first to review this product!

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Supplement Overview

Item Catalog Number: 01511
30 Capsules
Also available with Melatonin
Click to View Supplement Facts

Life Extension Enhanced Natural Sleep without Melatonin contains clinically validated Lactium and Sendara to support healthy, restful sleep, promote healthy response to stress, while targeting sleep debt-related factors associated with skin aging.

The consequences of sleep deprivation go far beyond fatigue and diminished performance. Decades of clinical research document that a good night's rest supports nearly all systems of the body, including: skin health and youthful appearance,94-97 healthy collagen formation,98-101 insulin levels already within normal range,102-104 healthy body weight,105,106 glucose levels already within normal range,107,108 blood pressure already within normal range,109,110 healthy cell division,111-113 cardiovascular health,114-117 and a good mood.118-120

Scientists attribute sleep-related difficulties to the unprecedented levels of stress most of us endure in today's fast-paced world. And to add insult to injury, sleep quality and duration decline as we grow older - at a time when we need the health benefits of a good night's rest more than ever.

Bioactive Milk Peptides (Lactium®) are a cutting-edge nutrient complex consisting of patented bioactive peptides found naturally in milk. Used widely in Europe to promote sustained and restful sleep patterns, published studies reveal that these bioactive milk peptides also promote relaxation, help with stress, and support daytime cognition.121-123 A group of 63 women reporting a variety of sleep-related difficulties experienced as much as 65.6% improvement in their symptoms with just 150 mg per day of these bioactive milk peptides.124 In another study, the same 150 mg dose induced substantial improvements across 27 markers of sleep quality and stress response in 165 healthy adults.125 And in a third study, a group of healthy men and women taking 150 mg per day of these bioactive milk peptides for one month experienced a 50% improvement in sleep quality after two weeks and needed 30% less time to fall asleep after 4 weeks.125

Sendara is a proprietary nutrient complex consisting of ashwagandha and Indian gooseberry extracts. Prized in traditional cultures for their ability to promote healthy skin function and appearance, these plant-based compounds have since gained substantial clinical validation. Indian gooseberry provides broad-spectrum antioxidant support and has been used to preserve youthful skin health and appearance in many skin care products.127-130 Ashwagandha also promotes a healthy response to stress, yielding 62% relaxation support compared to placebo with just 125 mg per day in one clinical study.131

If you don't sleep well with melatonin - or are already taking one of Life Extension's standalone melatonin formulas at a different dose that works for you - we also offer Enhanced Natural Sleep® without Melatonin.

Supplement Facts

Serving Size: 1 capsule

Servings Per Container: 30

Amount Per Serving

Sendara [proprietary blend of Ashwagandha (Withania somnifera) extract (root and leaf) standardized to withanolide glycoside conjugates and Amla (Phyllanthus emblica) extract (fruit) standardized to low molecular weight hydrolysable tannins]

200 mg

Casein decapeptide (Bioactive Milk Peptides)

150 mg

Other Ingredients: vegetable cellulose (capsule), microcrystalline cellulose, vegetable stearate, silica. Contains milk (casein decapeptide).

Patent pending Sendara is a trademark of Nutragenesis, LLC.
Lactium® is used under license.

Dosage and Use:

  • Take one capsule daily, with or without food, or as recommended by a healthcare practitioner. May be taken during daytime for stress or before bed to help with sleep.


  • If pregnant, nursing, or taking medication, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose


94. J Invest Dermatol. 2001 Aug;117(2):309-17.
95. Arerugi. 2010 Jun;59(6):706-15.
96. Dermatitis. 2007 Jun;18(2):82-91.
97. J Invest Dermatol. 2005 Mar;124(3):587-95.
98. The Physiology and Pathophysiology of the Skin. London: Academic Press; 1980:2147-55.
99. Sleep Med Rev. 2005 Oct;9(5):355-64.
100. Curr Opin Pulm Med. 2005 Nov;11(6):481-4.
101. Nat Rev Neurosci. 2009;10(3):199-210.
102. Obes Rev. 2009 Nov;10 Suppl 2:37-45.
103. BMC Public Health. 2007 Jun 28;7:129.
104. Science. 2010 Dec 3;330(6009):1349-54.
105. J Clin Sleep Med. 2007 Dec 15;3(7):681-8.
106. Obesity (Silver Spring). 2009 Apr;17(4):767-71.
107. Int J Obes (Lond). 2009 Jan;33(1):46-53.
108. Am J Physiol. 1996 Aug;271(2 Pt 1):E261-70.
109. Am J Hypertens. 2010 Dec;23(12):1286-91.
110. Lakartidningen. 2002 Jan 17;99(3):154-7.
111. Occup Med (Lond). 2010 Jan;60(1):10-20.
112. Chronobiol Int. 2011 Feb;28(1):76-80.
113. Lipids Health Dis. 2010 Oct 30;9:125.
114. Prog Cardiovasc Dis. 2009 Jan-Feb;51(4):294-302.
115. Prog Cardiovasc Nurs. 2004 Spring;19(2):56-9.
116. Sleep. 2010 Aug 1;33(8):1037-42.
117. Sleep. 2009 Mar 1;32(3):295-301.
118. J Sleep Res. 1997 Sep;6(3):179-88.
119. Psychiatry Clin Neurosci. 2003 Jun;57(3):265-70.
120. Principles and Practice of Sleep Medicine. 3rd ed. Philadelphia, PA: WB Saunders; 2000:1140-57.
121. The Open Sleep Journal 2009, 2, 26-32
122. Eur J Nutr. 2005 Mar;44(2):128-32.
123. Hypertens Res. 2011 Sep;34(9):1035-40.
124. Eur J Clin Nutr. 2007 Apr;61(4):536-41.
125. So Ken Study: Effect of Lactium® on sleep disorders. October, 2006.
126. BMC Med. 2010 Aug 16;8:51.
127. Skin Pharmacol Appl Skin Physiol. 2002;15(5):374-80.
128. J Surg Res. 2008;144(1):94-101.
129. J Ethnopharmacol. 2010 Oct 28;132(1):109-14.
130. J Cosmet Sci. 2009;60(4):395-403.
131. JANA. 2008;11(1):50-6.

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

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