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Life Extension Arginine Ornithine Powder, 150 grams

Item Number: 00038 | Be the first to review this product!

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Supplement Overview

Item Catalog Number: 00038
150 grams (5.29 oz) Powder
Click to View Supplement Facts

Life Extension Arginine Ornithine Powder contains ingredients that supports ammonia detoxification, the immune system, and the heart and arteries. It may provide support for healthy tissue and bone, increased strength and muscles, and help stimulate.

L-arginine is a semi-essential amino acid involved in numerous areas of human biochemistry, including ammonia detoxification, hormone secretion, and immune modulation. Arginine is also well known as a precursor to nitric oxide (NO), a key component of endothelial-derived relaxing factor, an endogenous messenger molecule involved in a variety of endothelium-dependent physiological effects in the cardiovascular system.

L-ornithine is a metabolite of arginine in the body, formed as a byproduct of the action of the arginase enzyme on arginine.66 L-arginine is required for the body to synthesize nitric oxide,67,68 which enables the arterial system to retain its youthful elasticity. Nitric oxide also helps to produce an endothelial-derived relaxing factor, which is needed by the arterial system to expand and contract with each heartbeat.69-78

L-arginine may also help stimulate the immune system.79-83

Surgical or traumatic injury greatly increases the body’s need for L-arginine, a key building block to maintaining healthy tissue and bone. L-ornithine may also be used for this purpose.84-94

Some studies suggest that either independently or combined, arginine and ornithine appear to stimulate growth hormone (GH) based on the increase in strength and muscle mass that was produced while intensely working out.95-97 Other research evidences ornithine’s ability to stimulate GH release.98-103 Another study showed a combination of ornithine with acetyl-L-carnitine enhanced the GH release feedback loop.104 However, studies suggest that low doses of L-arginine and/or L-ornithine are unlikely to effect GH release. A minimum dose of L-arginine to promote GH release is probably 5 to 9 grams.96

L-arginine and L-orinithine are used for heart and blood vessel conditions such as congestive heart failure, angina, high blood pressure, and coronary artery disease.1 Blood vessels relax due to the nitric oxide and this may improve circulation.4 Other uses include increasing muscle, total strength and lean body mass.2 The combination also supports the body's ability to stimulate growth hormone.3

Supplement Facts

Serving Size: 1 level teaspoon (approx. 3.1 g)

Servings Per Container: about 48

Amount Per Serving

L-Arginine hydrochloride

2.25 g

L-Ornithine hydrochloride

750 mg

Other Ingredients: none

Dosage and Use:

  • Take one level teaspoon on an empty stomach, or as recommended by a healthcare practitioner.


  • If pregnant, nursing, or taking medication, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose


1. MedlinePlus: L-arginine
2. Effects of arginine and ornithine on strength, lean body mass and urinary hydroxyproline in adult males.
3. Arginine and ornithine supplementation increases growth hormone and insulin-like growth factor-1 serum levels after heavy-resistance exercise in strength-trained athletes.
4. WebMD: Arginine: Heart Benefits and Side Effects
64. Srp Arh Celok Lek. 2009 Nov-Dec;137(11-12):594-600. Serbian.
65. Int J Clin Pharmacol Ther. 2005 Feb;43(2):71-7. Erratum in: Int J Clin Pharmacol Ther. 2005 Jun;43(6):304.
66. Biomed Pharmacother. 2002 Nov;56(9):439-45.
67. Curr Vasc Pharmacol. 2011 Nov 21. [Epub ahead of print]
68. Biochem Biophys Res Commun. 2011 Nov 4;414(4):660-3.
69. Aktuelle Urol. 2009 Aug;40(4):235-41.
70. Biorheology. 2009;46(2):107-19.
71. Bull Mem Acad R Med Belg. 2006;161(10-12):529-36; discussion 536-7.
72. Can J Physiol Pharmacol. 2005 Aug-Sep;83(8-9):681-700.
73. J Thorac Cardiovasc Surg. 1995 Aug;110(2):302-14.
74. Biochem Biophys Res Commun. 1988 Jun 30;153(3):1251-6.
75. J Nutr. 2000 Nov;130(11):2626-9.
76. Clin Cardiol. 2000 Mar;23(3):205-10.
77. Hypertens Pregnancy. 2007;26(1):121-30.,
78. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E906-12.
79. Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):80-7.
80. Amino Acids. 2009 Jul;37(2):323-31.
81. Nutrition. 2006 Jul-Aug;22(7-8):705-12.
82. Curr Opin Clin Nutr Metab Care. 2004 Jan;7(1):45-51.
83. Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):223-8.
84. Gut. 1994 Jan;35(1 Suppl):S42-5.
85. Surg Clin North Am. 2003 Jun;83(3):571-96.
86. Clin Nutr. 1993 Feb;12(1):61-2.
87. Isr Med Assoc J. 2002 Sep;4(9):713-6
88. Ann Surg. 2002 Sep;236(3):369-74; discussion 374-5.
89. Am J Clin Nutr. 1997 Feb;65(2):512-8.
90. Eur J Clin Nutr. 2000 Aug;54(8):615-7.
91. Curr Opin Clin Nutr Metab Care. 2000 Jan;3(1):59-66.
92. J Nutr. 1998 May;128(5):797-803.
93. J Parenter Enteral Nutr. 1995 May-Jun;19(3):227-30.
94. Ann Fr Anesth Reanim. 1995;14 Suppl 2:102-6.
95. J Strength Cond Res. 2010 Apr;24(4):1082-90.
96. Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):50-4.
97. J Sports Med Phys Fitness. 1989;29(1):52-6.
98. Burns Incl Therm Inj. 1987;13(5):349-56.
99. CRC Press Boca Raton 1997 pg 130
100. Nutrition. 1991;7(5):313-22
101. Clin Nutr. 1999;18(4):209-17.
102. Endokrynol Pol. 1986;37(1):11-5.
103. J Trauma. 1984;24(7):590-6.
104. Med Hypotheses. 2001 May;56(5):610-3.

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

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