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Blood Testing, Sex Hormone Binding Globulin, SHBG

Item Number: LC082016 | Be the first to review this product!

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List Price: $44.00
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Supplement Overview

Item Catalog Number: LC082016
Click for Blood Testing Information



Testosterone and estradiol circulate in the bloodstream, bound mostly to SHBG (sex hormone binding globulin) and to some degree other blood proteins. Only a small fraction of the sex hormones are unbound, or "free," and thus biologically active and able to enter a cell and activate its receptor.

SHBG decreases the active form of the hormone available to the tissues. Thus bioavailability of sex hormones is influenced by the level of SHBG. High levels of insulin and androgens decrease SHBG level. On the other hand, thyroid hormone and estrogen increase it.

Conditions with low SHBG include ovarian cysts, diabetes, and hypothyroidism. Conditions with high SHBG include pregnancy, hyperthyroidism, and anorexia. There has recently been research to link high SHBG levels with breast and testicular cancer as well.

Fasting is not required for this test. Take all medications as prescribed. Do not take supplements the day of the test.

This test is included in the following panels:

  • Male and Female Comprehensive Panels
  • Male and Female Weight Management Panels


Special Note:


References: Oral contraceptives will invalidate hormone results.

1. SHBG


The blood test services are for informational purposes only. It is not the intention of National Diagnostics, Inc, Life Extension, and DR Vitamin Solutions to provide specific medical advice but rather provide users with information to better understand their health. Specific medical advice including diagnosis and treatment will not be provided. Always seek the advice of a trained health professional for medical advice, diagnosis, or treatment.

Both the physician and the test laboratory are independent contractors with whom National Diagnostics, Inc makes arrangements for your blood tests. Neither National Diagnostics, Inc, Life Extension, nor DR Vitamin Solutions will be liable any acts or commissions of the physician, the testing laboratory, or their agents or employees.

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