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Zetpil TTFD Coenzyme B1 Chelating Creme, Thiamine Tetrahydrofurfuryl Disulfide, 50 mg, 4 oz Bottle

Item Number: TTFD04 | Be the first to review this product!

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Supplement Overview

Item Catalog Number: TTFD04
4 oz Bottle

Transdermal application is an efficient way of administering TTFD, which has been used to support Autism, Energy Production, Memory, Glucose Metabolism, Carbohydrate Metabolism, and as a Heavy Metal Chelator for Arsenic, Cadmium, Nickel, Lead, and Mercury. Absorbs through the skin directly into the bloodstream without degradation in the stomach or liver as with oral supplements. Much more effective!

Supplement Facts

Serving Size: 1 pump
Servings Per Container: 120

Amount Per Serving

B1/Thiamine Tetrahydroxyfurfury Disulfide

50 mg

Cream Base: Purified water, PEG-sorbitan monolaurate, 1,2,3 hydroxypropane, helianthus annuus seed oil, tinctorius seed oil, cocoa butter, theobroma cacao, coconut oil, wheat germ oil, shea butter, medicina aloe, lecithin, mixed phospholipids, polysaccharide derivatives, rosemary oil extract, citrus seed extract, citric acid, ascorbic acid and potassium sorbate.

Dosage and Use:

  • Apply 1 ml (1 pump) two to three times per day on clean, dry skin or as directed by a healthcare professional.


  • If pregnant or lactating, consult your physician before taking this product
  • For topical use only.
  • Avoid eyes and mucous membranes.
  • Do not exceed recommended dose

Contraindications: This product is contraindicated in persons with known hypersensitivity to phospholipids, sesame seeds or any of the ingredients. If you experience any adverse effect, discontinue and contact your healthcare provider.

Note: This product can be stored at room temperature or in the refrigerator prior to use.


As co-enzymes, the B vitamins are essential components in most major metabolic reactions. They play an important role in energy production, including the metabolism of lipids, carbohydrates, and proteins. B vitamins are also important for blood cells, hormones, and nervous system function. As water-soluble substances, B vitamins are not generally stored in the body in any appreciable amounts (with the exception of vitamin B-12). Therefore, the body needs an adequate supply of B vitamins on a daily basis.

Thiamine (Vitamin B-1) is an essential coenzyme in energy production. Thiamine is converted quickly into thiamine pyrophosphate, which is required for glycolytic and Krebs cycle reactions. Thiamine also appears to be related to nerve impulse transmission.

Defenses against oxidative stress largely employ key endogenous antioxidant enzymes, many of which require redox-sensitive thiol groups in their active sites. Impaired oxidative metabolism and energy failure, due to loss of reducing equivalents, eventually leads to selective region-specific neuronal loss and diminished thiamine-dependent enzymes. The key enzyme involved here is transketolase (EC (TK), which is a thiamine diphosphate-dependent enzyme that couples the non-oxidative branch of the pentose phosphate pathway (PPP) with the glycolytic pathway. The sugar phosphates generated by PPP are used for intermediary biosynthesis, nucleic acid synthesis and NADPH for reductive biosynthesis (Schenk, Duggleby et al. 1998).

Since thiamine is critical for transketolase function, thiamine deficiency diminishes thiamine dependent enzymes, disrupts mitochondrial function and leads to diminished energy metabolism and the production of NADPH. Gibson and Zhang (Gibson and Zhang 2002) found that interactions involving oxidative stress, together with abnormal thiamine homeostasis, promoted neurodegeneration in a number of chronic neurological diseases.

Both TTFD and vitamin B1 activate the transketolase enzyme and thiamine is important in glucose metabolism as it drives the flux of metabolites through the hexose mono-phosphate shunt. Further, TTFD can be used in cases of sulfur depletion, TTFD is expected to act as a sulfate donor during its metabolism. It is suggested that TTFD acts as a metal-chelating agent as well.

Nerve cells are particularly sensitive to thiamine deficiency and our data on transketolase in ASD may be important to understanding the disease in light of B1 deficiency or insufficiency, which could affect neuronal function and potentially brain development or contribute to the development of the ASD phenotype. Loss of these brain cells has been noted during ischemia, hypoxia, excitotoxicity, G-protein dysfunction, viral infection, heavy metal toxicity and deficiency of both thiamine and magnesium (Kern 2002). In that regard, the significance of dysautonomia in ASD can be illustrated by Beriberi, the nutritional disease from thiamine deficiency, which is considered the prototypic model for early stages of dysautonomia (Inoouye 1965). However, this must be distinguished from frank thiamine deficiency (Platt 1967). Kern and Jones (Kern and Jones 2006) noted that loss of Purkinje cells in the cerebellum is a consistent finding in autopsy studies of autistic patients. This is also a consistent finding in Wernicke Korsakoff syndrome (Butterworth 1993), a pathological finding also reported to occur in children (Vasconcelos, Silva et al. 1999). Simon discussed evidence that brain damage in infantile autism may involve the same complex of brainstem nuclei that are damaged by alcohol abuse, thiamine deficiency, and asphyxia (Simon 1990). The most metabolically active structures in the brain make them vulnerable to many injurious factors. The high metabolic rate in brainstem nuclei supports a control function for multiplexing of neural pathways. If this control is lost it may result in the defects of awareness and responsiveness seen in autistic children (Simon 1990). TTFD Cream is an easy form for these children to supplement vitamin B1.

Vitamin B and all of its forms have been identified as supporting energy production in the human body. Almost all forms of Vitamin B are water soluble. One particularly important form of Vitamin B - B1 or Thiamine - can be found in both a water soluble and fat soluble form. Thiamine and its fat soluble brother Thiamine Tetrahydrofurfuryl Disulfide - or TTFD as its better known – and has piqued the interest of many scientist for some time now.

Thiamine is well known to support carbohydrate metabolism - an important issue in today's diabetes-prone carbohydrate-centric society. There have been many theories explored as to how Thiamine supports carbohydrate metabolism, but like most scientific studies, the more one digs the more it keeps unfolding.

Thiamine's benefits as a glucose supporting agent are so sure that even the US Government's established RDA is based upon a 0.5 Mg per 1000 calories of dietary consumption as opposed to a milligram-per-pound-of-body-weight like other vitamins.

Thiamine, and more importantly -TTFD, helps to regulate blood glucose by effecting the production of ATP which is the fuel for cellular energy. Recent research has shown that TTFD may be a superior form of B1 and its benefits might be just what we need to help so many pre-diabetics, diabetics and athletes achieve something that they all share in common - superior glucose management and excess glucose disposal.

Some studies with TTFD have been shown to enhance glucose utilization and glucose oxidation in both resting and athletic performance settings. This fat soluble form of B1 is absorbed easily by the body, leads to higher blood levels of Thiamine than frank Thiamine supplementation and appears to pass the blood-brain-barrier effectively. Since the Brain requires precise glucose utilization those suffering from CNS-related disease like Alzheimer's Disease should pay attention to this form of B1. Non-caffeinated energy drinks would also do well to pay attention to this form of B1 since its effects on alertness and cognition may outperform their favorite form of Thiamine. And ergoneic supplement formulators out there may do well to add TTFD to their Creatine / Beta Alanine blends as this form of B1 should have a complimentary effect on performance and staving off fatigue.

TTFD has also been shown in some limited experiments to have a positive effect on Autistic children who are well known to have digestive and nutrient assimilation issues. In one study 8 out of 10 Autistic children saw improvement in their symptoms with doses of 50 Mgs twice daily for 2 months.

As we age Thiamine appears to have greater importance. Both its absorption and its enzymatic contributions diminish. Getting adequate amounts of B1 - and perhaps it superior form TTFD - may be essential to healthy aging. A naturally occurring food source of TTFD can be found in Garlic where this fat soluble form of B1 was first discovered. TTFD is released when the Garlic is sliced or crushed.

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

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