Item Catalog Number: 01292
150mg - 60 Vegetarian Capsules
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The original IGOB131 African Mango Integra Lean Irvingia Gabonensis Extract used in Life Extension is the original irvingia raw material from Cameroon Africa that was used in the published studies. Don't be fooled by cheap African mango imitations that are inferior in potency and quality.

DR Vitamin Solutions Note:

It takes several weeks to restore the sensitivity of the body's leptin receptors. Studies show that weight management is noticeably greater during the second half of treatment with Irvingia (weeks 5 to 10) than during the first half (weeks 1 to 5). We therefore recommend taking Irvingia for at least 10 weeks. Studies have also shown better results when Irvingia is NOT combined with a Low Carb diet. A high fiber diet in complex carbohydrates is optimum

Works great with Irvingia

For the ultimate weight management combination, try Integra Lean Irvingia and Brazilian Lean together.

What is African Mango

Life Extension African Mango Integra Lean:

The Original Irvingia Used in Studies

Scientists have identified specific biological mechanisms that cause aging people to gain weight... no matter how little they eat. The problem was that there was no way to circumvent the underlying factors that cause excess body fat... until now! As you are about to learn, gaining control over your body's command signals is critical to maintaining a healthy weight.

Leptin is a hormone that tells our brain that we have consumed enough calories and can stop eating. Leptin also induces a process whereby fat stored in cells is broken down. As we age, our cells (including the appetite control center in our brains) become "leptin resistant." This means that leptin is unable to effectively regulate body weight.

Adult-onset weight gain is characterized by the enlargement of existing adipocytes (fat cells) that store too much fat. The size of fat cells is controlled by gene transcription factors. Fat cell size is closely related with adiponectin expression - with reduced adiponectin expression in larger fat cells. In addition, gene transcription factors help regulate adiponectin, and this crucial hormone is critical for supporting insulin sensitivity.

An enzyme called glycerol-3-phosphatedehydrogenase is critical for synthesizing fatty acids in our bodies. Suppressing this enzyme helps reduce the amount of glucose (sugar) in our bloodstream from being converted into fatty acids.

Weight management utilizing diet modification, supplements, hormones or drugs usually functions via a single mechanism. Adipocytes (fat cells), on the other hand, possess numerous means to ensure their survival. An extract from a West African plant called Irvingia has been shown to help maintain healthy body weight in four ways:

1. Reversing Leptin Resistance

Fat cells produce C-reactive protein, a pro-inflammatory compound that leads to "leptin resistance." Overweight people given Irvingia have lower levels of CRP, and therefore less CRP is able to block the activity of leptin. Leptin is important in weight management because it promotes the breakdown of fat in adipocytes and tells the brain to turn off chronic hunger messages.

2. Increasing Adiponectin

Large fat cells secrete less adiponectin, and adiponectin is a crucial hormone that helps support insulin sensitivity as well as cardiovascular health. Overweight people given Irvingia show markedly increased adiponectin levels.

3. Inhibiting the Fat Converting Enzyme

An enzyme called glycerol-3-phosphate dehydrogenase facilitates the conversion of glucose into triglycerides that increase adipocyte size. Irvingia inhibits glycerol-3-phosphate dehydrogenase, thus reducing the amount of glucose (sugar) that is converted to fat in the body.

4. Reducing Carbohydrate Absorption

In order for carbohydrates to be fully absorbed, they must be broken down in the digestive tract by the amylase enzyme. Irvingia inhibits amylase, and thus reduces the amount of ingested starches that will be absorbed as sugar.

Several studies demonstrate the weight management properties of Irvingia. In the largest placebo controlled human study, those taking Irvingia lost 28 pounds over a 10-week period compared to only up to 3 pounds in the placebo group. The study participants did not alter their diet.

Based on impressive human data, a dose of 150 mg of Integra-LeanTM Irvingia taken twice a day is all that was needed to achieve unprecedented clinical results.

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.

Important Information If You Recently Ordered

It takes several weeks to restore the sensitivity of the body's leptin receptors. Studies show that weight management is noticeably greater during the second half of treatment with Irvingia (weeks 5 to 10) than during the first half (weeks 1 to 5). We therefore recommend taking Irvingia for at least 10 weeks. Studies have also shown better results when Irvingia is NOT combined with a Low Carb diet. A high fiber diet in complex carbohydrates is optimum.

If you only ordered one bottle of Life Extension African Mango Integra, please realize that was only enough for 4 weeks. Please do not evaluate your results on just one bottle. As the owner and health adviser of DR Vitamin Solutions, I am called to serve you; not money. I am simply trying to help you achieve the best results possible, and if you have room in your budget, I urge you to order one or two more bottles for the incredible full effect of the original IGOB131 Life Extension African Mango Integra Lean Irvingia.

To help make this more affordable, please remember to use coupon code save10 at the checkout to take an additional 10% off your order. That is over $2.00 off each bottle for a price of $18.90 each

Integra-Lean® Irvingia is protected by U.S. Patent No. 7,537,790. Other patents pending.

Dosage and Use:

• Take one capsule twice daily with or without food, or as recommended by a healthcare practitioner.

Fat cells (adipocytes) secrete a hormone called leptin that tells our brain we have eaten enough. Leptin can also facilitate the breakdown of stored triglycerides in our adipocytes via the process of lipolysis. Heavy individuals have startlingly high blood levels of leptin, indicating that their cells have become resistant to the leptin that is supposed to prevent them from putting on so many fat pounds.

An extract from an African mango called Irvingia gabonensishas been shown to help support leptin sensitivity in overweight people. In a recently published study,irvingia demonstrated beneficial effects upon leptin blood levels, followed by weight management and inches off the waistline.⁴⁹ In addition to supporting healthy leptin sensitivity, irvingia has demonstrated the following beneficial effects on key aspects of metabolism:

• Glycerol-3-phosphate dehydrogenase is an enzyme involved in the complex biochemical process that converts ingested starch and sugar calories to stored body fat. Irvingia has been shown in studies involving fat cells to reduce the activity of glycerol-3-phosphate dehydrogenase, which may help reduce the impact of starch and sugar calories on body fat.⁵⁰
• Scientific research on fat cells suggests that irvingia has alpha-amylase-inhibiting properties (like InSea2 and Phaseolus vulgaris)^TM which can help support a slowing of the rate of carbohydrate absorption from the intestines and a reduction of the caloric impact of starchy and sugary foods.^51-52
• Adiponectin is a hormone involved in helping to maintain insulin sensitivity on the membranes of energy-producing cells. Big fat cells produce less adiponectin, and overweight people need to be especially concerned about maintaining healthy levels of adiponectin to support insulin sensitivity and metabolic fitness. Scientific data suggests that irvingia helps support healthy adiponectin levels.⁵⁰

Based on impressive human clinical data that supports weight management of over 20 pounds on average in 10 weeks,⁴⁹ this standalone formula of an African mango extract, Integra-Lean® Irvingia, is also available to help promote optimal weight.

Please note: This product is designed to target several critical factors involved in age-related weight gain. Those who ingest more calories than what their body has the metabolic capacity to utilize will not see results. This is because some people are ingesting so many excess calories that no matter how much their metabolic rate is increased, or how much improvement occurs in their post-meal blood sugar and serum triglyceride levels, or by how much youthful insulin sensitivity and other body fat-regulating systems are restored, they are overwhelming the metabolic capacity to utilize these calories. This will result in excess calories being stored in adipocytes. One cannot consume limitless calories and expect to shed fat pounds by taking drugs, nutrients, and/or hormones that demonstrate weight-loss effects in clinical studies.

Research Links:

• Obesity

Warnings:

• If pregnant or lactating, consult your physician before taking this product
• Keep out of reach of children
• Do not exceed recommended dose

References:

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.