Account Login

We Are Here to Serve You

Get Coupons by Email!

About Life Extension

Established in 1980, the Life Extension Foundation is a 501 (c) (3) non profit organization dedicated to finding new scientific methods for eradicating old age, disease and death. The largest organization of its kind in the world, the Life Extension Foundation has always been at the forefront of discovering new scientific breakthroughs for use in developing novel disease prevention and treatment protocols to improve the quality and length of human life. Read More

About Metagenics

At Metagenics, patient health is our greatest concern. Metagenics has built a reputation on nutraceuticals and medical foods that meet the high expectations of health care professionals worldwide. But what we care about most is serving the best interests of the patients who use our products and services with a goal of improving health and reversing chronic illness. Read More

About Pure Encapsulations

Pure Encapsulations was founded to formulate and manufacture the highest quality line of hypo-allergenic supplements available... Pure Encapsulations supplements are hypoallergenic. All two-piece capsules are hypoallergenic and vegetarian. There are absolutely no added coatings, binders, shellacs, artificial flavors, artificial sweeteners or colors, fragrance or excipients in our products that would disrupt or diminish the bioavailability of any of their ingredients. Read More

About Zetpil

Zetpil-RX is the health care professional's top choice for highly absorbed suppository forms of DMSA, Glutathione, Amino Acids, Iron, and more. This method offers an effective solution for individuals that suffer from poor and/or inadequate intestinal absorption, or for those that are in a deteriorated state of health. Products support the Prostate, Brain & Memory, Stress Reduction, Detoxification, and a variety of nutritional deficiencies. Zetpil suppositories provide support for Diabeties, Heart Disease, Cancer, and so many other debilating dieases. Read More

Gift Certificates

Adding Product

Use the drop down below to add this product to one of your existing autoships. This product will be purchased and shipped alongside the other products in that autoship.



Add to Autoship

Nutricology 90 Percent Honokiol plus Magnolol, Magnolia Bark Extract, 200mg, 120 Vegetarian Capsules

Item Number: 56390 | Be the first to review this product!

Earn $0.61 Reward Points with this purchase! (Learn More!)
List Price: $42.00
Our Price: $24.50
Your Savings: $17.50
Quantity:
Auto Reorder?
What's This?
Login or Register


Product Overview

Item Catalog Number: 56390
120 Vegetarian Capsules
Click to View Supplement Facts

Nutricology 90 Percent Honokiol plus Magnolol, Magnolia Bark Extract contains the highest concentration of Honokiol and Magnolol available. Supports Stress, Depression, Anxiety, and in larger doses, Mood Enhancement. Also supports Cancer, Cardiovascular Health, Memory and Brain Support and Nerve Function and is an aphrodesiac.

May support:

  • Stress, Depression, Anxiety, and in larger doses, Mood Enhancement
  • Research with Cancer
  • Nitric Oxide (NO) Production
  • Cardiovascular Health
  • Memory and Brain Support
  • Nerve Function
  • Immune Function
  • Antiseptic and Bactericidal
  • Muscle Spasms
  • Aphrodisiac for Sexual Enhancement
  • Diuretic for Weight Loss
  • Expectorant for Mucus
  • Stomach Tone Support as a Stomachic

Honokiol is a biphenolic compound present in the cones, bark, and leaves of Magnolia grandifloris that has been used in the traditional Japanese medicine Saiboku-to as an anxiolytic, antithrombotic, anti-depressant, anti-emetic, and anti-bacterial. While early research on the effective compounds in traditional remedies have simply used whole magnolia bark extracts, known as houpu magnolia, recent work has identified honokiol and its structural isomer magnolol as the active compounds in magnolia bark. In the late 1990s, honokiol saw a revival in western countries as a potent and highly tolerable anti-tumorigenic and neurotrophic compound.


Anti-Tumorigenic Activities

Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, and colon cancer cell lines. Honokiol inhibits phosphorylation of Akt, mitogen-activated protein kinase (MAPK), and src. Additionally, honokiol modulates the nuclear factor kappa B (NF-κB) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2), and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. So potent is honokiol's pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple myeloma and chronic B-cell leukemia.


Neurotrophic Activity

Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons.


Anti-thrombolytic Activity

Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density lipoprotien injury. Honokiol significantly increases the prostacyclin metabolite 6-keto-PGF1alpha, potentially the key factor in honokiol's anti-thrombotic activity.


Stress and Depression

In research, honokiol has shown potential to selectively modulate GABA receptors, and protect and support nerve function (Fukuyama 2002; Maruyama 2001; Maruyama 1998; Kuribara 1998;), and support healthy circulation parameters (Hu 2005; Teng 1988).* Honokiol may also exhibit some immune-supportive properties (Shigemura 2007; Ishitsuka 2005; Battle 2005; Bai 2003; Amblard 2006; Taira 1993; Clark 1981; Chang 1994; Hirano 1994; Wang 2004; Hibasami 1998; Konoshima 1991; Yang 2002).* Research results suggest that the mixture of honokiol and magnolol possessed potent antidepressant-like properties in behaviors involved in normalization of biochemical abnormalities in brain 5-HT and 5-HIAA, serum corticosterone levels and platelet AC activity in the CMS rats. The findings could provide a basis for examining directly the interaction of the serotonergic system, the HPA axis and AC-cAMP pathway underlying the link between depression and treatment with the mixture of honokiol and magnolol.


Discussion

Magnolia extract has been used in both the Japanese and Chinese traditions for several thousand years. In Traditional Chinese Medicine (TCM), magnolia is called Hou Po; in Japan it is used in the Kampo preparation Hange koboku-to, as well as others. While traditional herbal preparations utilize whole magnolia bark extract, modern research has identified two biphenolic compounds, honokiol and its structural isomer magnolol, as the primary active compounds in magnolia bark. Both naturally occur together in the magnolia plant, and the only difference between the two isomers is the position of one hydroxyl group. Magnolia also contains other active ingredients, including eudesmol, a triterpene compound with antioxidant properties.

TCM considers Hou Po magnolia bark to be aromatic, pungent, and warming, and has used it for thousands of years as support for healthy digestion.* It has been used for “chi stagnation”, to help combat the effects of stress, and to support calm, healthy moods.* This may be explained through magnolia’s potential support of cortisol.* The bark of Magnolia officinalis was traditionally considered to be antiseptic, antispasmodic, aphrodisiac, appetizer, diuretic, expectorant, stomachic, tonic, and possibly bactericidal.


Supplement Facts

Serving Size: 1 Vegetarian Capsule
Servings Per Container: 120

Amount Per Serving

Magnolia (Bark) Extract (90% Honokiol + Magnolol)

200 mg

Other Ingredients: Hydroxypropyl methylcellulose, microcrystalline cellulose, L-leucine


Dosage and Use:

  • Take 1 - 4 capsules daily, or as directed by a healthcare practitioner.


Warnings:

  • May cause drowsiness. Do not operate a motor vehicle or other machinery after ingesting.
  • If pregnant or lactating, consult your physician before taking this product
  • Keep out of reach of children
  • Do not exceed recommended dose


References:

Fukuyama Y, Nakade K, Minoshima Y, Yokoyama R, Zhai H, Mitsumoto Y. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1163-6.
Maruyama Y, Kuribara H, Kishi E, Weintraub ST, Ito Y. J Pharm Pharmacol. 2001 May;53(5):721-5.
Maruyama Y, Kuribara H, Morita M, Yuzurihara M, Weintraub ST. J Nat Prod. 1998 Jan;61(1):135-8.
Kuribara H, Stavinoha WB, Maruyama Y. J Pharm Pharmacol. 1998;50: 819-826.
Hu H, Zhang XX, Wang YY, Chen SZ. Acta Pharmacol Sin. 2005 Sep;26(9):1063-8.
Teng CM, Chen CC, Ko FN, et al. Thromb Res. 1988;50: 757-765.
Shigemura K, Arbiser JL, Sun SY, et al. Cancer. 2007 Apr 1;109(7):1279-89.
Ishitsuka K, Hideshima T, Hamasaki M, et al. Blood. 2005 Sep 1;106(5):1794-800. Epub 2005 May 3.
Battle TE, Arbiser J, Frank DA. Blood. 2005 Jul 15;106(2):690-7. Epub 2005 Mar 31.
Bai X, Cerimele F, Ushio-Fukai M, et al. J Biol Chem. 2003 Sep 12;278(37):35501-7. Epub 2003 Jun 19.
Amblard F, Delinsky D, Arbiser JL, Schinazi RF. J Med Chem. 2006 Jun 1;49(11):3426-7. Taira J, Ikemoto T, Mimura K, Hagi A, Murakami A, Makino K. Free Radic Res Commun. 1993;19(suppl 1): S71-77. Clark AM, El-Feraly FS, Li WS. J Pharm Sci. 1981;70: 951-952. Chang WS, Chang YH, Lu FJ, Chiang HC. Anticancer Res. 1994;14: 501-506. Hirano T, Gotoh M, Oka K. Life Sci. 1994;55: 1061-1069. Wang T, Chen F, Chen Z, et al. World J Gastroenterol. 2004;10: 2205-2208. Hibasami H, Achiwa Y, Katsuzaki H, et al. Int J Mol Med. 1998;2: 671-673. Konoshima T, Kozuka M, Tokuda H, et al. J Nat Prod. 1991;54: 816-822. Yang SE, Hsieh MT, Tsai TH, Hsu SL. Biochem Pharmacol. 2002;63: 1641-1651.


* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.

Related Products

Life Vitality Ultra Bliss Mood Enhancer, 120 grams, Vegetarian Powder

Ultra Bliss is the most effective and potent mood enhancer available. Results in 10 to 20 minutes. Made with a balance of amino acids, and works by normalizing chemicals in the brain. Promotes relaxation and mood ...

Metagenics Benesom, 60 Tablets

Metagenics Benesom, 60 Tablets

Item Number: BEN

Our Price: $57.25
Add to Favorites

Formulated to promote a restful, relaxed state and relieve occasional sleeplessness by beneficially modulating the metabolism of melatonin and GABA. Benesom features melatonin a hormone produced ...

Metagenics Serenagen, 60 Vegetarian Tablets

Metagenics Serenagen is a classic herbal stress management formula used in traditional Chinese medicine (TCM) to nourish and quiet the heart. Living a demanding, hectic lifestyle deeply influences mood, mental ...

Pure Encapsulations 5-HTP 50 mg, 180 Vegetarian Capsules

Pure Encapsulations 5-HTP encourages brain serotonin levels that can lead to positive effects on emotional well-being, stress, weight loss, sleep/wake cycles and appetite control. May promote healthy cranial ...

Pure Life Gaba-Max Stress and Anxiety Formula, 120 grams Powder

Pure Life Gaba-Max Stress and Anxiety Formula, ...

Item Number: GABMAX120pdr

Our Price: $57.95
Add to Favorites

GabaMax promotes relaxation and enhances mood within minutes. Use small amounts daily to reduce stress, anxiety, depression, increase lean muscle, decrease fat, improve immunity, improve clarity & focus, ...

Zetpil Mind Motivator Suppositories, 30 Count

Zetpil Mind Motivator Suppos ...

Item Number: ZTL009

Our Price: $89.95
Add to Favorites

A natural solution to increase energy without the crash like those from caffeine drinks. Supports cognitive abilities, memory, mood, mental clarity, concentration, alertness and focus. Acts to support cerebral ...


Customers also purchased

Drucker Labs IntraMAX 100% Organic 415  Nutrient, All In One Liquid Vitamin Supplement, 33 oz Liquid

Drucker Labs IntraMAX 100% Organic 415 ...

Item Number: INTM33OZ

Our Price: $80.00
Add to Favorites

IntraMAX organic liquid supplement provides carbon bond organic trace minerals using IntraCELL V technology to produce a highly absorbable bioavailable liquid supplement. IntraMAX supports immune system, ...

Vision Clarity Carnosine Eye Drops, 2 Vials per box each 5 ml, Cataracts, Dry Eye, more

Pharmaceutical Grade, certified to be free of all contaminants as shown by a Certificate of Analysis. Contains N-acetyl-L-carnosine; a unique form of the dipeptide carnosine. Over 8 years of impressive support for ...

Life Vitality Brazilian Lean with Acai, 60 Capsules

A highly effective weight loss formula, Brazilian Lean with Acai supports lower cholesterol levels, enhanced metabolism, and acts as an appetite suppressant. Higher energy levels and increased burning of ...

Life Vitality Ultra Bliss Mood Enhancer, 120 grams, Vegetarian Powder

Ultra Bliss is the most effective and potent mood enhancer available. Results in 10 to 20 minutes. Made with a balance of amino acids, and works by normalizing chemicals in the brain. Promotes relaxation and mood ...


Product Reviews

Add Your Review

Please log in to leave a review.
Authorize.Net Merchant - Click to Verify This site protected by Trustwave's Trusted Commerce program DR Vitamin Solutions is an Upfront Merchant on TheFind. Click for info. Nextag Seller

More About Our Security