Item Catalog Number: 56390
120 Vegetarian Capsules
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Nutricology 90 Percent Honokiol plus Magnolol, Magnolia Bark Extract contains the highest concentration of Honokiol and Magnolol available. Supports Stress, Depression, Anxiety, and in larger doses, Mood Enhancement. Also supports Cancer, Cardiovascular Health, Memory and Brain Support and Nerve Function and is an aphrodesiac.

May support:

• Stress, Depression, Anxiety, and in larger doses, Mood Enhancement
• Research with Cancer
• Nitric Oxide (NO) Production
• Cardiovascular Health
• Memory and Brain Support
• Nerve Function
• Immune Function
• Antiseptic and Bactericidal
• Muscle Spasms
• Aphrodisiac for Sexual Enhancement
• Diuretic for Weight Loss
• Expectorant for Mucus
• Stomach Tone Support as a Stomachic

Honokiol is a biphenolic compound present in the cones, bark, and leaves of Magnolia grandifloris that has been used in the traditional Japanese medicine Saiboku-to as an anxiolytic, antithrombotic, anti-depressant, anti-emetic, and anti-bacterial. While early research on the effective compounds in traditional remedies have simply used whole magnolia bark extracts, known as houpu magnolia, recent work has identified honokiol and its structural isomer magnolol as the active compounds in magnolia bark. In the late 1990s, honokiol saw a revival in western countries as a potent and highly tolerable anti-tumorigenic and neurotrophic compound.

Anti-Tumorigenic Activities

Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, and colon cancer cell lines. Honokiol inhibits phosphorylation of Akt, mitogen-activated protein kinase (MAPK), and src. Additionally, honokiol modulates the nuclear factor kappa B (NF-κB) activation pathway, an upstream effector of vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2), and MCL1, all significant pro-angiogenic and survival factors. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. So potent is honokiol's pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple myeloma and chronic B-cell leukemia.

Neurotrophic Activity

Honokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons.

Anti-thrombolytic Activity

Honokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density lipoprotien injury. Honokiol significantly increases the prostacyclin metabolite 6-keto-PGF1alpha, potentially the key factor in honokiol's anti-thrombotic activity.

Stress and Depression

In research, honokiol has shown potential to selectively modulate GABA receptors, and protect and support nerve function (Fukuyama 2002; Maruyama 2001; Maruyama 1998; Kuribara 1998;), and support healthy circulation parameters (Hu 2005; Teng 1988).* Honokiol may also exhibit some immune-supportive properties (Shigemura 2007; Ishitsuka 2005; Battle 2005; Bai 2003; Amblard 2006; Taira 1993; Clark 1981; Chang 1994; Hirano 1994; Wang 2004; Hibasami 1998; Konoshima 1991; Yang 2002).* Research results suggest that the mixture of honokiol and magnolol possessed potent antidepressant-like properties in behaviors involved in normalization of biochemical abnormalities in brain 5-HT and 5-HIAA, serum corticosterone levels and platelet AC activity in the CMS rats. The findings could provide a basis for examining directly the interaction of the serotonergic system, the HPA axis and AC-cAMP pathway underlying the link between depression and treatment with the mixture of honokiol and magnolol.

Discussion

Magnolia extract has been used in both the Japanese and Chinese traditions for several thousand years. In Traditional Chinese Medicine (TCM), magnolia is called Hou Po; in Japan it is used in the Kampo preparation Hange koboku-to, as well as others. While traditional herbal preparations utilize whole magnolia bark extract, modern research has identified two biphenolic compounds, honokiol and its structural isomer magnolol, as the primary active compounds in magnolia bark. Both naturally occur together in the magnolia plant, and the only difference between the two isomers is the position of one hydroxyl group. Magnolia also contains other active ingredients, including eudesmol, a triterpene compound with antioxidant properties.

TCM considers Hou Po magnolia bark to be aromatic, pungent, and warming, and has used it for thousands of years as support for healthy digestion.* It has been used for “chi stagnation”, to help combat the effects of stress, and to support calm, healthy moods.* This may be explained through magnolia’s potential support of cortisol.* The bark of Magnolia officinalis was traditionally considered to be antiseptic, antispasmodic, aphrodisiac, appetizer, diuretic, expectorant, stomachic, tonic, and possibly bactericidal.

Dosage and Use:

• Take 1 - 4 capsules daily, or as directed by a healthcare practitioner.

Warnings:

• May cause drowsiness. Do not operate a motor vehicle or other machinery after ingesting.
• If pregnant or lactating, consult your physician before taking this product
• Keep out of reach of children
• Do not exceed recommended dose

References:

Fukuyama Y, Nakade K, Minoshima Y, Yokoyama R, Zhai H, Mitsumoto Y. Bioorg Med Chem Lett. 2002 Apr 22;12(8):1163-6.
Maruyama Y, Kuribara H, Kishi E, Weintraub ST, Ito Y. J Pharm Pharmacol. 2001 May;53(5):721-5.
Maruyama Y, Kuribara H, Morita M, Yuzurihara M, Weintraub ST. J Nat Prod. 1998 Jan;61(1):135-8.
Kuribara H, Stavinoha WB, Maruyama Y. J Pharm Pharmacol. 1998;50: 819-826.
Hu H, Zhang XX, Wang YY, Chen SZ. Acta Pharmacol Sin. 2005 Sep;26(9):1063-8.
Teng CM, Chen CC, Ko FN, et al. Thromb Res. 1988;50: 757-765.
Shigemura K, Arbiser JL, Sun SY, et al. Cancer. 2007 Apr 1;109(7):1279-89.
Ishitsuka K, Hideshima T, Hamasaki M, et al. Blood. 2005 Sep 1;106(5):1794-800. Epub 2005 May 3.
Battle TE, Arbiser J, Frank DA. Blood. 2005 Jul 15;106(2):690-7. Epub 2005 Mar 31.
Bai X, Cerimele F, Ushio-Fukai M, et al. J Biol Chem. 2003 Sep 12;278(37):35501-7. Epub 2003 Jun 19.
Amblard F, Delinsky D, Arbiser JL, Schinazi RF. J Med Chem. 2006 Jun 1;49(11):3426-7. Taira J, Ikemoto T, Mimura K, Hagi A, Murakami A, Makino K. Free Radic Res Commun. 1993;19(suppl 1): S71-77. Clark AM, El-Feraly FS, Li WS. J Pharm Sci. 1981;70: 951-952. Chang WS, Chang YH, Lu FJ, Chiang HC. Anticancer Res. 1994;14: 501-506. Hirano T, Gotoh M, Oka K. Life Sci. 1994;55: 1061-1069. Wang T, Chen F, Chen Z, et al. World J Gastroenterol. 2004;10: 2205-2208. Hibasami H, Achiwa Y, Katsuzaki H, et al. Int J Mol Med. 1998;2: 671-673. Konoshima T, Kozuka M, Tokuda H, et al. J Nat Prod. 1991;54: 816-822. Yang SE, Hsieh MT, Tsai TH, Hsu SL. Biochem Pharmacol. 2002;63: 1641-1651.

* These statements have not been evaluated by the Food and Drug Administration. This Product is not intended to diagnose, treat, cure or prevent any disease.