Item Catalog Number: ZTL003
260mg - 25 Suppositories
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Considerations When Using DMSA
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Zetpil DMSA suppositories are used by doctors to effectively and efficiently remove Organic & Inorganic mercury, & other heavy metals from the body. Made of a sulfur-containing organic compound, in an advanced absorption enhancing proprietary, all natural base. Provides 100% absorption into the bloodstream of nutraceuticals via suppository without degradation in the stomach or liver as with oral supplements. Much more effective!

• The only extensively research based compound for the effective removal of all four common toxic elements: Mercury, Lead, Cadmium and Arsenic.
• Little or no gastrointestinal side effects seen with the oral form of DMSA.
• More effective and significantly less costly than intravenous CaNa2EDTA
• Less side effects than the painful intramuscular injectable mercury chelator DMPS
• A safe chelator that does not affect iron, calcium or magnesium levels
• An innovative proprietary all natural therapeutic suppository base in an easy to use, non-irritating, comfortable base

The Zetpil DMSA Suppository consists of meso-2, 3-dimercaptosuccinic acid (DMSA), a sulfur-containing organic compound) in an advanced absorption enhancing proprietary all natural base designed to effectively and efficiently support detoxification of Organic and Inorganic mercury as other heavy metals.

DMSA has been known to be an effective heavy metal chelator for mercury as well as lead arsenic and cadmium since the 1950s. In fact Meso-2, 3-dimercaptosuccinic acid (DMSA), has been studied for the past 50 plus years with the initial studies taking place in the People's Republic of China, Japan, and Russia and then eventually in Europe and the USA. Currently, research has shown DMSA to be the accepted first choice for the chelation of Organic and Inorganic Mercury, Lead, Arsenic, Cadmium, Antimony, Tin and Tungsten (Relative Affinities of Chelating Agents for Metals) Reference: Kemper (1990) Aposhian, Toxicology (1996) 97:23-38). Note that the Zetpil CaNa(2)EDTA Suppository is an effective supportive choice for Lead, Cadmium, Aluminum, Nickel, Antimony and Tin. Currently the FDA has approved DMSA for the treatment of lead, mercury, cadmium and arsenic toxicity in children and adults.

Dosage and Use:

• Based on your doctors recommendation, 1 suppository every one (1) to two (2) days.
• It is recommended that the Zetpil Multivitamin and Mineral suppository be taken every day throughout the course of treatment with the Zetpil DMSA suppository.
• It is highly recommended you attempt to clear your bowels prior to inserting a suppository to avoid premature evacuation after the suppository has been inserted.
• To facilitate insertion it is recommended you moisten suppository with warm water. Zetpil suppositories require a minimum of 20-30 minutes in the rectum to ensure adequate absorption of the ingredients. If inserted while lying on one’s side, consider remaining in the supine position for 10 minutes following insertion.
• Please click here for Important Considerations When Using DMSA
  

Pediatric Use:

• DMSA has been used safely in children. However, the safety and efficacy in pediatric patients less than 12 months of age has not been established. Zetpil DMSA suppositories should NOT be taken unless you are under the supervision of a qualified health care professional.

Geriatric Use:

• Dose selection for an elderly patient start at the low end of the dosing range (1-2 suppository(s) per day) reflecting a consideration of concomitant disease or other drug therapy.

Contraindications:

• This product is contraindicated in individuals with a known hypersensitivity phospholipids, sesame seeds or any of the ingredients should avoid taking this product.

Warnings:

• DMSA should not be used by pregnant or lactating women.
  
• Keep this product out of the reach of children.
• Do not use if the suppositories are open or damaged.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down
• Store away from heat and direct light.
• As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.
• Do not exceed recommended dose.

Note: This product must be stored at room temperature from 59 degrees Fahrenheit to 86 degrees Fahrenheit. Do not store in the refrigerator or freezer. If the suppository does become soft, place the suppository in the refrigerator for approximately 10 minutes only immediately prior to insertion to achieve the firmness needed for comfortable insertion.

If you experience any adverse effect, discontinue and contact your healthcare provider before resuming use. This product contains no hidden coatings, excipients, binders, fillers, shellacs, artificial colors, fragrance, diary, wheat, egg, yeast, gluten, corn, sugar, starch, preservatives or hydrogenated oils.

Discussion:

Why Is the Chelation of Heavy Metals So Important?

Mercury contamination is most often associated with fish consumption, mercury amalgam dental fillings, mercury preservatives in vaccines, and other modern industrial exposures. Historically, lead contamination has been connected mainly to lead-based paints and leaded gasoline, both of which have been discontinued. However, children can still be exposed to old lead-based paint, and lead contamination is still an issue in areas where lead is being mined or smelted.

Other heavy metals include cadmium and arsenic, which are derived mainly from cigarette smoke but also from occupational and environmental exposures.

It has long been recognized that sulfur-containing compounds have the ability to chelate heavy metals. Within the normal operation of the human body, there are natural sulfur-containing compounds include N-acetyl-Cysteine (NAC), R-lipoic acid, S-adenysyl methionine (SAMe), and glutathione (GSH), however these compounds have proven to more of adjunctive compounds and less effective when significant heavy metal toxicity is present.

The Zetpil DMSA Suppository is an Effective and Preferred Heavy Metal Chelator

Chemically, DMSA is a dithiol, which means that it contains two sulfhydryl (also know as S-H) groups.

• Urinary mercury excretion is significantly increased by DMSA administration versus CaNa(2)EDTA. (Roels)
• DMSA mobilized Lead mainly from soft tissue, especially blood, brain, kidney and liver. With respect to redistribution of mobilized lead to critical organs and magnitude of decline in soft tissue lead concentration, DMSA appears to be a safe and particularly effective chelator and thus may be a viable alternative or choice where to CaNa(2)EDTA has proven irritating or less effective (Cory-Slechta)
• DMSA-chelated lead mainly reflects lead chelated from lead concentrations in the blood, soft tissues, and possibly also trabecular bone. (Gerhardsson)
• Chelation therapy with DMSA in adults with moderate to severe lead poisoning is effective and safe. (Lifshitz)
• Like CaNa(2)EDTA, DMSA reverses (only) some of the lead-induced immunotoxicity (Chen). Therefore the use of the adjunctive (additional) Zetpil oral antioxidant nutraceutical, nutrient protocol during the use of the Zetpil DMSA Suppository DMSA and post treatment protocol for the reactive oxidative stress and reactive nitrogen stress has been developed to facilitate the recovery of the brain and organs from the chronic immunotoxic insult caused by long term heavy metal immunotoxicity.
• Evidence exists that DMSA is effective in lowering the blood lead concentrations in children with levels between 25 and 45 micrograms/dL.” (Berlin) and is considered safe and effective in children at recommended doses under the supervision of a qualified healthcare professional.
• DMSA administration stimulates arsenic excretion in the urine. (Maehashi)
• DMSA acts as an antioxidant in vitro and lowers blood pressure in lab animals. (Khalil-Manesh)
• DMSA does not affect excretion of iron, calcium or magnesium. (Facts & Comparisons) However, DMSA may increase the excretion of zinc and copper. Therefore the use of the specially formulated Zetpil Oral Multivitamin and Mineral during the course of treatment with the Zetpil DMSA Suppository is recommended.
• The Zetpil DMSA Suppository is recommended as a single chelating agent only. Although there has been some discussion and animal studies demonstrating the use of DMSA and CaNa(2)EDTA, this combination has not been evaluated to any large extent in humans and accordingly is NOT RECOMMENDED.

The Zetpil DMSA Suppository Makes More Sense than Oral DMSA

• Clinical experience has shown an absorption rate via rectal suppository, to be approximately 99% absorption via the rectum whereas DMSA taken orally, is poorly absorbed (approximately 20%) with blood level peaks in 2-4 hours. Excretion is much slower, with a half-life of approximately 2 days. (Facts & Comparisons). The peak blood levels do not differ appreciably.
• There are essentially no gastrointestinal side effects with the therapeutic dosage delivered via the Zetpil DMSA Suppository whereas oral DMSA has demonstrated a high incidence of gastrointestinal side effects including nausea, vomiting, diarrhea, appetite loss, hemorrhoidal symptoms, loose stools, metallic taste in mouth, back pain, abdominal cramps, stomach pains, gastritis, fever, flu-like symptoms, headache and Candida Albicans over growths.

The Zetpil DMSA Suppository is Safe

DMSA has a large “therapeutic window”, meaning that there is a wide margin between the amount needed to produce desired results and the amount that is potentially toxic. The Zetpil DMSA Suppository greater absorbability allows for the use of a lower effective dosage as well as the virtual elimination of the many of the systemic and gastrointestinal side effects associated with oral DMSA.

Important Considerations When Using DMSA

We strongly urge you to work with your doctor when supplementing with DMSA. Here are some links that may be of interest when talking to your doctor:

• Heavy Metal Toxicity Physiological Effects
• The 5 Most Toxic Heavy Metals
• DMSA – EDTA Comparison Chart
• Urine Toxic & Essential Elements, Tests for Essential and Toxic Elements 
• View Sample Urine Test Report

Most clients start with DMSA if they have high levels of Mercury, and typical dosage is one Zetpil DMSA Suppository every other night for 25 days.  Most clients need to repeat this for 4 to 6 months depending on the severity. After which, if there are still levels of lead showing from a urinalysis, then Zetpil EDTA is recommended at a rate of one a night for 30 to 60 days.

We have found that there have been some clients with such high mercury levels, that the "feel" of the detox may be uncomfortable.  Although DMSA is a safe and effective cost effect method of chelation, it is not without some issues. One is transient elevation of liver enzymes. In order to prevent this issue, it is imperative that when using DMSA one needs to also take an advanced anti-oxidant program to minimize the potential liver issues as well as the damage that occurs when heavy metals are chelated out of the body.

As with any regimen, there are considerations and these considerations need to be addressed so that the necessary removal of the heavy metals does not create another set of problems.  The protocol developed by Zetpil and Zetpil was created to insure that your chelation experience will be safe, effective, and well tolerated.

At DR Vitamin Solutions we understand chelation of heavy metal is an important step, and their removal should be both an effective and side effect free experience to maximize the health benefits that occur when heavy metals are effectively removed from the body using the Zetpil & Zetpil protocol.

The Zetpil DMSA protocol consists of the Following:

• DMSA
• Melatonin Cream or Melatonin Suppositories
• Reduced Glutathione Suppositories or Reduced Glutathione Spray Pump
• Taurine
• NAC Cream
• Vitamin C with Dihydroquercetin or Vitamin C and R-Lipoic Acid Drops
• Multi Vitamin Mineral Plus or Hemepoietin (same as multi-mineral Plus, except also includes Iron if needed).

For mercury removal we also recommend Arginine Suppositories with DMSA. When Arginine (not oral) is combined with DMSA, the combination pulls mercury out of the blood vessels as well.  DMSA alone only gets it out of the kidneys organs, and adipose tissue.

For some rare forms of poisoning many clients use Reduced Glutathione Plus Suppositories.

Additional Uses for DMSA

• DMSA along with EDTA is used as a challenge test for heavy metal intoxication when used in combination with urinalysis, fecal, and hair heavy metal testing: Doctors Data Testing for Metals, Parasites, more
• Dialkyltin compounds have been widely used in industry and agriculture, mainly as biocides, catalysts and plastic stabilizers. Toxic effects occur in the immune system, the bile duct, liver and pancreas. In a manner similar to organic arsenic, the toxicity of the dialkyltin compounds is related to reactions with biological dithiol groups. DMSA diminishes the production of bile duct, pancreas and liver lesions and inhibits the development of fibrosis of the pancreas and cirrhosis of the liver in lab animals exposed to these toxic chemicals. The decrease in the biliary excretion of these compounds by DMSA seems to be the reason for the pronounced protective effects of DMSA on bile duct, pancreas and liver. For these reasons DMSA has been recommended for the treatment of poisonings with dibutyltin compounds. (Merkord).
• DMSA is also being evaluated for use in the prevention of cystine kidney stones in patients with homozygous cystinuria with individuals prone to stone development.
• Elevated heavy metal levels may cause or help exacerbate conditions as far ranging as decreased circulation, degenerative diseases such as Alzheimer’s, Diabetes, decreased Adrenal gland function and Autism. The human body requires about 70 trace elements/minerals for optimal function such as magnesium, zinc, copper and manganese but there are several heavy metals that are classified as toxic to human physiology and include lead, mercury, aluminum, arsenic, cadmium and nickel. These harmful heavy metals have no place in the human body and may be toxic even at very low levels; therefore the need to remove them is great. For this fact alone Chelation therapy with The Zetpil DMSA Suppository OR the Zetpil CaNa(2)EDTA should be considered as a “key step to any intelligent nutritional or detoxification regimen".

How To Insert Rectal Suppositories

1. Wash your hands thoroughly with soap and water. Prior to using/inserting suppositories, it is best to attempt to evacuate by attempting to have a bowel movement. We recommend, if possible, that the suppositories be inserted after you have attempted to move your bowels. This helps in the first of the four pharmacokinetic processes: absorption, distribution, metabolism, elimination (Hollenberg & Brody, 1998). If you chose to use a latex glove to insert the suppository, place the glove on the hand you will use to insert the suppository. Gloves are very inexpensive gloves can be purchased at most pharmacies.
2. Take the suppository out of the refrigerator. The suppositories retain cold so they will be comfortable. By keeping the suppository in the refrigerator, the suppository will be hard and easier to insert. ONLY the DMSA suppository cannot be refrigerated or kept in freezer since the cold decreases potency.
3. Open plastic suppository shell by pulling apart the 2 tabs located at the tapered end.
4. If necessary, lubricate the suppository tip with tap water or a water-soluble lubricant such as K-Y Lubricating Jelly, NOT PETROLEUM JELLY (VASELINE). If you do not have this lubricant, moisten the SUPPOSITORY with cool tap water. Note that after a shower, insertion is quite easy. Note that the use of the lubricating jelly and/or cool water will hasten the separation of the base material form the nutrients, and thus enhance the absorption process.
5. Lie on your side with your lower leg straightened out and your upper leg bent forward toward your stomach.
6. Lift upper buttock to expose the rectal area.
7. Insert the suppository flat side first (not the tapered end pushing with your finger until it passes the muscular sphincter of the rectum, about 1/2 to 1 inch in infants and 1 inch in adults. ) By inserting the flat end first retention and post insertion comfort is improved. If the suppository is not inserted past this sphincter muscle, the suppository may pop out (see below). The placing of the flat side first into the rectum triggers a reflex contraction of the rectal tissue that causes the suppository to be pulled up into the rectum where it is more comfortably retained.
8. Hold buttocks together for a few seconds and you are finished!
9. Discard used materials and wash your hands thoroughly. If you have used a latex glove, pull the glove inside out then discard. Remember, if you have problem with retaining the suppository, a simple strategy to insure retention is to lying down for about 5-15 minutes as this will help you retain the suppository.

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